Simple spit test could spot lung cancer early

NCT ID NCT07168993

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study is testing a new test called FlowPath Lung that looks for signs of lung cancer in sputum (phlegm). It involves over 2,000 high-risk individuals aged 50-80 who have lung nodules found on CT scans. The goal is to see if this non-invasive test can accurately detect early-stage lung cancer, potentially offering a simpler alternative to more invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could provide a simple, non-invasive sputum test to catch lung cancer early, potentially reducing the need for biopsies and improving survival rates.
What could go wrong
This is a diagnostic accuracy study, not a treatment trial. The test may not be accurate enough to replace current methods, and results may not apply to all populations.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Audie Murphy VA Medical Center

    RECRUITING

    San Antonio, Texas, 78234, United States

  • Bay Pines VA Healthcare System

    RECRUITING

    Bay Pines, Florida, 33744, United States

  • Brooke Army Medical Center

    RECRUITING

    San Antonio, Texas, 78234, United States

  • Captain James A. Lovell Federal Health Care Center

    RECRUITING

    North Chicago, Illinois, 60064, United States

  • Clinical Research Associates of Central Pennsylvania

    RECRUITING

    DuBois, Pennsylvania, 15801, United States

  • Dayton VA Medical Center

    RECRUITING

    Dayton, Ohio, 45428, United States

  • James A. Haley Veterans' Hospital

    RECRUITING

    Tampa, Florida, 33612, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Miami VA Healthcare System

    RECRUITING

    Miami, Florida, 33125, United States

  • VA Palo Alto Health Care System

    RECRUITING

    Palo Alto, California, 94304, United States

  • VA Western Colorado Health Care System

    RECRUITING

    Grand Junction, Colorado, 81501, United States

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