Which lung biopsy method is safer and more accurate?
NCT ID NCT07761351
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial compares two established biopsy methods for small lung nodules (≤2 cm): CT-guided percutaneous biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT. The goal is to see which approach is more effective at diagnosing cancer and which has fewer complications, such as pneumothorax (collapsed lung). Adults with a lung nodule needing biopsy may participate. The study will measure diagnostic accuracy and safety to help guide future clinical decisions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two biopsy procedures: shape-sensing robotic-assisted bronchoscopy with cone-beam CT (ssRAB with CBCT) and CT-guided percutaneous lung nodule biopsy
- What this could lead to
- If successful, this could help doctors choose the best biopsy method for small lung nodules, improving diagnostic accuracy and reducing complications like collapsed lungs.
- What could go wrong
- The trial is in phase 4 and involves 550 participants, but results may not apply to all patients or nodules. Both procedures carry risks, including bleeding or pneumothorax (collapsed lung).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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