Blood test may spot lung cancer early, avoiding unnecessary biopsies
NCT ID NCT07623473
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, and DNA changes. The goal is to improve lung cancer diagnosis and reduce the need for invasive procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Blood tests (protein tumor markers, epigenetic smoking marker, fragmentome/mutational/methylome analysis of cell-free tumor DNA)
- What this could lead to
- If successful, this could lead to a simple blood test that helps doctors quickly tell whether a lung nodule is cancerous or not, reducing unnecessary invasive procedures.
- What could go wrong
- This is an observational study, not a treatment trial. The blood tests may not be accurate enough to replace current diagnostic methods, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Gentofte Hospital
RECRUITINGGentofte Municipality, Denmark
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