Pulmonary coin lesion

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This early study tests whether a patient's own natural killer (NK) cells, given as infusions, are safe and can help shrink lung nodules. 24 adults with high-risk nodules will receive multiple doses. The main goal is to check for side effects within 28 days, with tumor response as…

This study is testing a blood test that looks for tumor DNA to see if it can more accurately tell whether a lung nodule found on a CT scan is cancer. About 590 people getting lung cancer screening will give blood samples and be followed for 3 years. The goal is to improve how we …

The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, …

This study tests an FDA-approved AI software that analyzes CT scans of lung nodules to estimate cancer risk. 300 adults aged 35-89 with newly found lung nodules will be randomly assigned to have their doctors use the AI tool or not. The goal is to see if the AI helps doctors mana…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This observational study is testing whether a breath test can accurately tell the difference between benign and malignant lung nodules. Researchers will analyze volatile organic compounds (VOCs) in the exhaled breath of 3,000 people with lung nodules. The goal is to develop an AI…

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study enrolls 25 smokers who have a suspicious lung nodule and need a biopsy or bronchoscopy. At their first visit, doctors strongly advise quitting and offer support like counseling and a free program. The study tracks how many patients successfully quit over 3 months, usin…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…