AI could help doctors spot lung cancer earlier, avoid unnecessary biopsies

NCT ID NCT05968898

Recruiting now Diagnosis Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an FDA-approved AI software that analyzes CT scans of lung nodules to estimate cancer risk. 300 adults aged 35-89 with newly found lung nodules will be randomly assigned to have their doctors use the AI tool or not. The goal is to see if the AI helps doctors manage nodules more appropriately—recommending monitoring for benign ones and prompt action for cancerous ones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Optellum Virtual Nodule Clinic (AI software device)
What this could lead to: If successful, this AI tool could help doctors more accurately identify which lung nodules are cancerous, leading to faster treatment for cancer and fewer unnecessary biopsies for benign nodules.
What could go wrong: This is a relatively small, early-stage trial (300 participants) testing a device already FDA-approved. The AI may not improve outcomes in all settings, and its effectiveness depends on how doctors use it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm pulmonary coin lesion

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER PULMONARY NODULE, SOLITARY

Contacts and locations

Locations

Penn Medicine University City
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Penn Medicine Washington Square
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Perelman Center for Advanced Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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