Could your genes raise your melanoma risk? new study seeks answers

NCT ID NCT00040352

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This study aims to understand how genetics and environmental factors contribute to melanoma, a serious skin cancer. Researchers will enroll up to 3,000 people with a personal or family history of melanoma or related conditions. Participants will fill out questionnaires, provide blood or cheek cell samples, and may undergo skin exams and biopsies to help identify risk genes and other factors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify genes and risk factors that help predict melanoma, leading to better screening and prevention strategies for high-risk families.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

large congenital melanocytic nevus melanoma melanoma, cutaneous malignant, susceptibility to, 2 skin neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYSPLASTIC NEVUS SYNDROME MELANOMA

Contacts and locations

Locations

National Cancer Institute (NCI)
RECRUITING

Bethesda, Maryland, 20892, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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