Ulcer of lower limbs

This trial tests a two-step treatment for chronic lower leg wounds that have not healed for over a month. First, a motorized waterjet cleans the wound, then a motion-based suction device applies negative pressure to promote healing. The study includes 50 adults with various types…

This study tests whether a repairing gel (Supraz) combined with a platelet-rich plasma-fibrin glue can eliminate odor and help heal chronic wounds that haven't improved with standard care. About 40 adults with a single wound lasting at least 3 months will receive either the new t…

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study tests whether adding special wound dressings (called CAMPs) to standard care helps close hard-to-heal diabetic foot and leg ulcers better than standard care alone. About 350 adults with these ulcers will be randomly assigned to receive either the extra dressings or usu…

This study tests whether adding cold plasma therapy to standard wound care helps heal large chronic leg ulcers faster. About 120 adults with non-healing wounds will receive either standard care alone or standard care plus a 4-week plasma treatment. The main goal is to see if the …

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This study looks at whether adding amniotic membrane products to standard wound care helps diabetic foot ulcers, venous leg ulcers, and pressure ulcers heal faster. Researchers will compare healing rates in 2,400 adults treated with these grafts versus those receiving standard ca…

This study looks at whether adding four types of amniotic membrane grafts to standard care helps heal chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers faster. Researchers will track 2,000 adults to see if wounds close completely within 12 weeks and…

This phase 3 trial tests a donor stem cell treatment called Allo-APZ2-CVU for people with chronic venous leg ulcers that haven't healed with standard therapy. About 250 adults with ulcers between 1 and 25 cm² will receive either the cell therapy or a placebo applied directly to t…

This study tests whether a special lipid cream (EpiCeram) can prevent healed chronic wounds—like diabetic foot ulcers or pressure sores—from reopening. About 100 adults with recently healed wounds will apply either the cream or Vaseline for 3 months. Researchers will measure skin…

This study compares a new device, cureVision cV, to an existing one (MolecuLight i:X) to see if it can accurately detect moderate to high levels of bacteria in wounds. About 100 adults with various wound types (like diabetic foot ulcers or surgical wounds) will be enrolled. The g…

This small study is testing Corplex P, a device made from donated human umbilical cord tissue, to see if it helps heal wounds that won't close on their own, like diabetic foot ulcers. Ten people will receive the device as part of their standard wound care. Researchers will track …

This study tests whether adding laser light therapy to standard wound care helps heal hard-to-heal ulcers in frail older adults receiving home healthcare. About 1,290 participants will receive the laser treatment on their wounds and nearby lymph areas. Researchers will track heal…

This study tests whether injecting platelet-rich plasma (PRP) directly into grade III ulcers can speed up healing. PRP is made from a small amount of the patient's own blood, processed to concentrate healing factors. Fifty adults with ulcers older than two weeks will receive eith…

This study was designed to test the safety and performance of the Avelle negative pressure wound therapy system on chronic wounds, including diabetic foot ulcers and venous leg ulcers. The device uses gentle suction to help wounds heal. However, the study was withdrawn before enr…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study looks at whether artificial intelligence (AI) can match a dermatologist's diagnosis when a general practitioner sends in photos and questions about a patient's skin condition. Researchers will compare the AI's diagnosis to the dermatologist's for about 1000 adults. The…

This study looks at how low-level laser therapy (red light at 660 nm) affects the stiffness of chronic and burn wounds. Researchers will measure stiffness before and after a 3-minute laser treatment using two devices: OCT and MyotonPRO. The goal is to see if laser therapy changes…