New hope for chronic leg pain: catheter procedure could reduce Post-Clot disability

NCT ID NCT03250247

Ongoing Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus standard care or standard care alone. The goal is to see if the procedure improves leg symptoms, quality of life, and ulcer healing.

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Conditions

The condition(s) this trial relates to.

post-thrombotic syndrome Postthrombotic Syndrome thrombotic disease ulcer of lower limbs Varicose Ulcer venous insufficiency venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VEIN THROMBOSIS POST THROMBOTIC SYNDROME VENOUS INSUFFICIENCY VENOUS LEG ULCER VENOUS REFLUX VENOUS STASIS

Contacts and locations

Locations

Christiana Care Hospital

Newark, Delaware, 19718, United States
Gundersen Health System

La Crosse, Wisconsin, 54601, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Jobst Vascular Institute

Toledo, Ohio, 43606, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
New York Presbyterian-Weill Cornell Medicine

NewYork, New York, 10065, United States
New York University Medical Center

New York, New York, 10003, United States
NorthShore University Health System

Evanston, Illinois, 60201, United States
Northwestern University

Evanston, Illinois, 60208, United States
Oregon Health & Sciences University

Portland, Oregon, 97239, United States
Rush Medical Center

Chicago, Illinois, 60612, United States
St. Elizabeth's Hospital

Lincoln, Nebraska, 68510, United States
St. Joseph's Vascular Institute

Orange, California, 92868, United States
Staten Island Hospital

Staten Island, New York, 10305, United States
Temple University

Philadelphia, Pennsylvania, 19140, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UCSF

San Francisco, California, 94143, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of North Carolina

Chapel Hill, North Carolina, 27517, United States
University of Oklahoma

Oklahoma City, Oklahoma, 73014, United States
University of Pittsburg

Pittsburgh, Pennsylvania, 15213, United States
University of Vermont Health Network - CVPH

Plattsburgh, New York, 12901, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

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