Venous insufficiency

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This study follows over 500 people with chronic venous disease who are taking Ruscus aculeatus L., a plant extract also known as butcher's broom, as part of their routine care. Researchers will track changes in vein-related symptoms, pain, and quality of life over 90 days. The go…

This trial compares two minimally invasive procedures for treating incompetent perforating veins—veins that fail to close properly and can cause leg swelling, skin changes, or ulcers. One method uses a needle to deliver an electric current to seal the vein, while the other inject…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive eit…

This study tests a new catheter system designed to remove blockages in leg veins caused by old blood clots. About 20 adults with painful swelling or pain from chronic vein blockages will receive the treatment. The main goals are to ensure the procedure is safe and to check if it …

This study is testing a new device called the Recana Thrombectomy Catheter System to treat chronic blockages in veins. It will include 30 adults with symptoms like leg swelling or pain due to venous obstruction. The device is inserted into the vein to remove the blockage and rest…

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This study tests whether using a simple urine test to guide the dose of a water pill (furosemide) can safely and effectively remove excess fluid after heart surgery. About 102 adults having heart surgery with a heart-lung machine will be randomly assigned to either standard care …

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This study tests whether a 3-week thermal spa treatment at the Saint-Eloy center can relieve symptoms of severe chronic venous insufficiency (a condition where leg veins have trouble sending blood back to the heart). About 84 adults with severe vein disease will receive either th…

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study compares two treatments for varicose veins: foam sclerotherapy (injecting a foam to close the vein) and mechanochemical ablation (using a device and medication). Both are done with local anesthesia and allow quick recovery. 50 patients will be randomly assigned to one …

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether using virtual reality during varicose vein surgery can reduce pain and anxiety enough to avoid standard sedation. About 400 adults will either receive virtual reality or standard medication. The goal is to see if VR can make the procedure more comfortable…

This study aims to see if a common vein treatment called radiofrequency ablation is safe and helpful for people aged 80 and older with severe chronic venous insufficiency. About 50 participants will receive the procedure and be followed for 6 months. The goal is to measure how we…

This study looks at whether vein problems are linked to pain, swelling, and daily function in women with lipedema. Researchers will use ultrasound to check leg veins and ask participants about their symptoms. The goal is to better understand how these conditions interact, which c…

This study looks at 400 people with a first-time deep vein thrombosis (DVT) in the leg. Researchers want to see if the amount of clot seen on an ultrasound can predict who will develop post-thrombotic syndrome (PTS), a condition causing long-term leg pain, swelling, and skin chan…

This study looks at whether people with hemorrhoids are more likely to have varicose veins in their legs. Researchers will use ultrasound to check the leg veins of 400 adults—200 with hemorrhoids and 200 without. No treatments or procedures are given; the goal is simply to see if…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study tests a new system that uses a special bandage with electrodes to monitor how well venous leg ulcers are healing. The system measures electrical signals through the wound and sends data to a phone app. Twenty adults with chronic leg ulcers will be monitored up to three…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This study looks at fetal cells that remain in a mother's blood after pregnancy, called fetal microchimeric cells, in women with chronic skin ulcers like venous or diabetic ulcers. Researchers will analyze these cells' genetic activity to see if they might help with wound healing…

The European Venous Registry (EVeR) is collecting data from 100 patients with deep vein disease in the legs to track how different treatments work over 10 years. Researchers will measure symptoms and quality of life to find out which approaches are most effective. This is an obse…