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Venous insufficiency
MONDO:0000945Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with edema and sometimes with venous stasis ulcers at the ankle.
Also known as: venous insufficiency, venous insufficiency (disease), peripheral venous insufficiency
229 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Heart drug tested to fight COVID-19 complications
Disease control TerminatedThis study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…
Phase: PHASE2, PHASE3 • Sponsor: Cardiol Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Experimental vein valve repair device tested in 14 patients, trial halted early
Disease control TerminatedThis study tested a device called the BlueLeaf System to fix faulty valves in leg veins of people with chronic venous insufficiency (CVI). The goal was to see if it could safely reduce backward blood flow and improve symptoms. Only 14 people took part before the trial was stopped…
Phase: NA • Sponsor: Intervene, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Glue vs. heat vs. knife: which vein fix wins?
Disease control TerminatedThis study tested a medical glue called VenaSeal against heat therapy or surgery for treating venous reflux, a condition where leg veins don't pump blood properly. About 500 adults with early to advanced vein disease took part. The goal was to see which method patients liked more…
Phase: NA • Sponsor: Medtronic Endovascular • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Varicose vein treatment showdown: foam vs. heat
Symptom relief TerminatedThis study compared two treatments for varicose veins: Varithena (a foam) and Endothermal Ablation (using heat). It included 43 adults with a faulty great saphenous vein. The goal was to see which treatment better reduced symptoms like heaviness and pain over 3 months.
Phase: PHASE4 • Sponsor: Boston Scientific Corporation • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New wound pump shows promise for stubborn leg ulcers
Symptom relief TerminatedThis study tested whether a single-use negative pressure wound therapy system (PICO) helps heal hard-to-treat venous leg ulcers better than standard care. About 142 adults with leg ulcers that had lasted at least 6 weeks took part. The main goal was to see if more ulcers healed c…
Phase: NA • Sponsor: Smith & Nephew, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Painkiller showdown: which is safer for the heart?
Knowledge-focused TerminatedThis study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…
Phase: PHASE4 • Sponsor: Platelet and Thrombosis Research, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC