Post-thrombotic syndrome

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This study tests a new catheter system designed to remove blockages in leg veins caused by old blood clots. About 20 adults with painful swelling or pain from chronic vein blockages will receive the treatment. The main goals are to ensure the procedure is safe and to check if it …

This study is testing a new device called the Recana Thrombectomy Catheter System to treat chronic blockages in veins. It will include 30 adults with symptoms like leg swelling or pain due to venous obstruction. The device is inserted into the vein to remove the blockage and rest…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a new MRI contrast agent called ferumoxytol, made from iron nanoparticles, to see if it can safely and effectively image veins in people with vein diseases. Current dyes can be risky for patients with kidney problems, but ferumoxytol may be safer and last longer …

This study looks at 400 people with a first-time deep vein thrombosis (DVT) in the leg. Researchers want to see if the amount of clot seen on an ultrasound can predict who will develop post-thrombotic syndrome (PTS), a condition causing long-term leg pain, swelling, and skin chan…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …