New device aims to suck out dangerous blood clots, sparing patients from Long-Term leg damage

NCT ID NCT05701917

Recruiting now Disease control Sponsor: Inari Medical Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either treatment. The goal is to see if the device better prevents long-term complications like chronic leg pain and swelling.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ClotTriever System (a device that mechanically removes blood clots)
What this could lead to: If it works, this could offer a more effective way to treat deep vein thrombosis and reduce the risk of long-term leg pain and swelling (post-thrombotic syndrome).
What could go wrong: This is a relatively early study with 300 participants, so results may not apply to everyone. The device procedure carries risks like bleeding or vessel damage, and it may not prove better than standard blood thinners.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

post-thrombotic syndrome Postthrombotic Syndrome venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VENOUS THROMBOSIS POST THROMBOTIC SYNDROME VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

Allegheny General Health Research Network
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Allegheny St. Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States
Aurora St. Luke's Medical Center
TERMINATED

Milwaukee, Wisconsin, 53215, United States
Baptist Health Research Institute
RECRUITING

Jacksonville, Florida, 32207, United States
BayCare Health System
RECRUITING

Tampa, Florida, 33607, United States
Charité - Universitätsmedizin Berlin
TERMINATED

Berlin, State of Berlin, 10117, Germany
Clements University Hospital (UTSW)
RECRUITING

Dallas, Texas, 75390, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Community Healthcare System
TERMINATED

Munster, Indiana, 46321, United States
Cooper University Hospital
RECRUITING

Camden, New Jersey, 08103, United States
Freeman Hospital Newcastle upon Tyne
RECRUITING

Newcastle upon Tyne, United Kingdom
GSST London/St Thomas
RECRUITING

London, United Kingdom
HCA Florida Largo Hospital
TERMINATED

Largo, Florida, 33770, United States
Helsinki University Hospital
RECRUITING

Helsinki, Finland
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States
Holy Name Medical Center
TERMINATED

Teaneck, New Jersey, 07666, United States
Honor Health
RECRUITING

Scottsdale, Arizona, 85258, United States
Huntington Health
RECRUITING

Pasadena, California, 91105, United States
Imperial College
RECRUITING

London, United Kingdom
Inselspital, Universitätsspital Bern
RECRUITING

Bern, Switzerland
Kantonsspital Baden
RECRUITING

Baden, Switzerland
Klinikum Hochsauerland GmbH
RECRUITING

Arnsberg, North Rhine-Westphalia, 59759, Germany
Lakeland Vascular Institute
TERMINATED

Lakeland, Florida, 33805, United States
Lexington Medical Center
TERMINATED

West Columbia, South Carolina, 29169, United States
Luzerner Kantonsspital
RECRUITING

Lucerne, Switzerland
MVZ CCB Frankfurt und Main-Taunus GbR
RECRUITING

Frankfurt am Main, Hesse, 60389, Germany
Manatee Memorial Hospital
TERMINATED

Bradenton, Florida, 34208, United States
McLaren Healthcare
RECRUITING

Bay City, Michigan, 48708, United States
MedStar Health Research Institution
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Memorial Health University Medical Center
TERMINATED

Savannah, Georgia, 31404, United States
Mercy Health - The Heart Institute
TERMINATED

Cincinnati, Ohio, 45211, United States
Mission Health
TERMINATED

Asheville, North Carolina, 28801, United States
MyMichigan Medical Center
RECRUITING

Midland, Michigan, 48670, United States
NYP-Brooklyn Methodist
RECRUITING

Brooklyn, New York, 11215, United States
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Northwell Health
RECRUITING

Bay Shore, New York, 11706, United States
Oxford - John Radcliffe
RECRUITING

Oxford, United Kingdom
Pima Heart and Vascular
RECRUITING

Tucson, Arizona, 85704, United States
Prisma Health Upstate
TERMINATED

Greenville, South Carolina, 29615, United States
Providence Sacred Heart Med Center
TERMINATED

Spokane, Washington, 99204, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
SUNY, The University at Buffalo
TERMINATED

Buffalo, New York, 14203, United States
Saint Francis Hospital
RECRUITING

Tulsa, Oklahoma, 74136, United States
Saint Luke's Hospital of Kansas City
TERMINATED

Kansas City, Missouri, 64131, United States
Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
St. Elizabeth Edgewood
TERMINATED

Edgewood, Kentucky, 41017, United States
St. Louis University
RECRUITING

St Louis, Missouri, 63104, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCI Medical Center
RECRUITING

Orange, California, 92868, United States
University Medical Center of Southern Nevada
RECRUITING

Las Vegas, Nevada, 89102, United States
University Of Colorado
RECRUITING

Denver, Colorado, 80045, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States
Universität Leipzig
RECRUITING

Leipzig, Saxony, 04109, Germany
Universitätsklinikum Augsburg
RECRUITING

Augsburg, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, Baden-Würtemberg, 72076, Germany
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Vascular and Interventional Specialists of Orange County
RECRUITING

Orange, California, 92868, United States
Vienna General Hospital (AKH Wien)
RECRUITING

Vienna, Austria
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.