Could a simple aspirin pill replace daily shots to prevent postpartum blood clots?

NCT ID NCT06494878

Recruiting now Prevention Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether taking a low-dose aspirin pill every day for six weeks after delivery can prevent dangerous blood clots in the legs or lungs as effectively as the standard daily heparin injections. The study enrolls people who have given birth and have one or more risk factors for blood clots. If aspirin proves non-inferior, it could offer a more convenient and less invasive prevention option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose aspirin (75-100 mg daily by mouth) compared to low-molecular-weight heparin injections
What this could lead to: If aspirin works as well as heparin, it could offer a simpler, pill-based way to prevent postpartum blood clots, reducing the need for daily injections.
What could go wrong: This is a large trial, but aspirin may prove less effective than heparin for some high-risk individuals. Bleeding risks with aspirin also need careful monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Postpartum Hemorrhage preeclampsia pulmonary embolism thrombophilia Venous Thrombosis venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASPIRIN LOW MOLECULAR WEIGHT HEPARIN POSTPARTUM PERIOD VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

APHP - Hôpital Port Royal
NOT_YET_RECRUITING

Paris, 75014, France
Amsterdam UMC
NOT_YET_RECRUITING

Amsterdam, 1105AZ, Netherlands
Association Hospitalière De Bruxelles Et De Schaerbeek - Centre Hospitalier Universitaire Brugmann
NOT_YET_RECRUITING

Brussels, 1020, Belgium
CHU de Nancy
NOT_YET_RECRUITING

Nancy, 54000, France
CHU de Saint-Etienne
NOT_YET_RECRUITING

Saint-Etienne, 42055, France
CHU de Toulouse
NOT_YET_RECRUITING

Toulouse, 31059, France
Foothills Medical Centre
RECRUITING

Calgary, Alberta, T2N 2T9, Canada
Hvidovre Hospital
NOT_YET_RECRUITING

Hvidovre, Capital Region, 2650, Denmark
Medical University of Warsaw
NOT_YET_RECRUITING

Warsaw, 02-091, Poland
Rotunda Hospital, RCSI Department of Obstetrics and Gynaecology
NOT_YET_RECRUITING

Dublin, D01 P5W9, Ireland
The Ottawa Hospital - General Campus
NOT_YET_RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
UCD Centre for Human Reproduction, The Coombe Hospital
NOT_YET_RECRUITING

Dublin, D08XW7X, Ireland

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