Glue vs. heat vs. knife: which vein fix wins?
NCT ID NCT03820947
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a medical glue called VenaSeal against heat therapy or surgery for treating venous reflux, a condition where leg veins don't pump blood properly. About 500 adults with early to advanced vein disease took part. The goal was to see which method patients liked more and how well it closed the bad veins.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VenaSeal™ System (medical adhesive)
What this could lead to
If successful, VenaSeal could offer a less painful, needle-free alternative to heat or surgery for closing faulty veins, improving recovery and satisfaction.
What could go wrong
The trial was terminated early, so results may be incomplete. Long-term effectiveness compared to standard treatments is still uncertain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azienda Ospedaliera di Padova Ospendale Sant' Antonio
Padova, 35127, Italy
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Bedfordshire Hospitals NHS Foundation Trust
Bedford, MK42 9DJ, United Kingdom
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CHU Dijon Bourgogne
Dijon, DIjon Cedex, 21079, France
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Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital
Cambridge, CB2 0QQ, United Kingdom
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Clinique Pasteur
Toulouse, France
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Clinique du Parc
Lyon, 69006, France
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Complejo Hospitalario Universitario Granada (Hospital Campus de la Salud)
Granada, 18016, Spain
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East Toronto Vascular Clinic
Toronto, Ontario, M4L 3Y3, Canada
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Gangnam Severance Hospital
Seoul, South Korea
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20007-2113, United States
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Imperial College Healthcare NHS Trust - Charing Cross Hospital
London, W12 0HS, United Kingdom
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Konkuk University Medical Center
Seoul, 143-729, South Korea
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Lake Washington Vascular
Bellevue, Washington, 98004-4623, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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New York-Presbyterian Hospital/Weill Cornell Medical Center
New York, New York, 10024, United States
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OhioHealth Riverside Methodist Hospital
Columbus, Ohio, 43214, United States
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Orion Medical
Houston, Texas, 77034, United States
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Ospedale Fatebenefratelli e Oftalmico
Milan, 20121, Italy
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PIMA Heart and Vascular
Tucson, Arizona, 85718, United States
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Praxis fur Innere Medizin und Gefäβkrankheiten
Halle, 06108, Germany
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Rijnstate - Locatie Arnhem
Arnhem, 6815, Netherlands
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Sanitas Hospital Universitario La Zarzuela
Madrid, 28023, Spain
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Seoul National University Hospital
Seoul, 110-744, South Korea
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Seoul Saint Mary's Hospital
Seoul, 137-701, South Korea
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Sunshine Coast University Hospital
Birtinya, 4575, Australia
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Valley Vascular Surgical Associates
Fresno, California, 93701, United States
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Vascular Care Connecticut
Darien, Connecticut, 06820, United States
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Vascular Care Group
Wellesley, Massachusetts, 02482, United States
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West London Vascular and Interventional Centre
Harrow, HA1 3UJ, United Kingdom
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Wollongong Hospital
Wollongong, Australia
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Yale School of Medicine
New Haven, Connecticut, 06510, United States
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Yavapai Regional Medical Center
Prescott Valley, Arizona, 86314-2255, United States