New pill may stop painful ulcers after liver banding procedure

NCT ID NCT07267260

Recruiting now Disease control Sponsor: King Edward Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether vonoprazan, a stomach acid blocker, can prevent ulcers that often form after endoscopic variceal band ligation (EVBL) in people with liver cirrhosis. About 154 adults will take either vonoprazan or a placebo daily for 14 days after the procedure. Researchers will check for ulcers with a follow-up endoscopy and track symptoms like pain and swallowing difficulty.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vonoprazan
What this could lead to: If it works, this could offer a simple daily pill to prevent painful ulcers and bleeding after a common procedure for liver cirrhosis patients.
What could go wrong: This is a small, early-phase study with only 154 participants. The results may not apply to all patients, and vonoprazan might not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CIRRHOSES, LIVER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cirrhosis of liver esophageal varices Fibrosis portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSES, LIVER

Contacts and locations

Locations

King Edward Medical University/Mayo Hospital
RECRUITING

Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.