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New eye drug EYE103 aims to restore vision in macular degeneration and vein occlusion

NCT ID NCT07205887

Recruiting now Disease control Sponsor: EyeBiotech Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four weeks apart. The study measures changes in vision and retinal thickness over 12 weeks to see if the drug can improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
EYE103 (Restoret), a humanized antibody injected into the eye
What this could lead to
If successful, this could lead to a new treatment option for wet age-related macular degeneration and macular edema from retinal vein occlusion, potentially improving vision and reducing retinal swelling.
What could go wrong
This is an early Phase 2 trial with only 160 participants, so results may not apply to everyone. The drug is still experimental, and side effects from eye injections (like infection or inflammation) are possible.

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Conditions

The condition(s) this trial relates to.

occlusion of tributary of retinal vein retinal vein occlusion wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRANCH RETINAL VEIN OCCLUSION (BRVO) NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NVAMD)

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Abilene, Texas

    RECRUITING

    Abilene, Texas, 79606, United States

    Contact Email: •••••@•••••

  • Amarillo, Texas

    RECRUITING

    Amarillo, Texas, 79106, United States

    Contact Email: •••••@•••••

  • Asheville, North Carolina

    RECRUITING

    Asheville, North Carolina, 28803, United States

    Contact Email: •••••@•••••

  • Austin, TX

    RECRUITING

    Austin, Texas, 78705, United States

    Contact Email: •••••@•••••

  • Austin, Texas

    RECRUITING

    Austin, Texas, 78705, United States

    Contact Email: •••••@•••••

  • Bellaire, TX

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact Email: •••••@•••••

  • Bellaire, Texas

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact Email: •••••@•••••

  • Bloomfield, NJ

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

    Contact Email: •••••@•••••

  • Bloomfield, New Jersey

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

    Contact Email: •••••@•••••

  • Burleson, Texas

    RECRUITING

    Burleson, Texas, 76028, United States

    Contact Email: •••••@•••••

  • Cary, North Carolina

    RECRUITING

    Cary, North Carolina, 27511, United States

    Contact Email: •••••@•••••

  • Dallas, TX

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Email: •••••@•••••

  • Dallas, Texas

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Email: •••••@•••••

  • Fort Lauderdale, FL

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

    Contact Email: •••••@•••••

  • Fort Lauderdale, Florida

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

    Contact Email: •••••@•••••

  • Germantown, Tennessee

    RECRUITING

    Germantown, Tennessee, 38138, United States

    Contact Email: •••••@•••••

  • Glendale, CA

    RECRUITING

    Glendale, California, 91204, United States

    Contact Email: •••••@•••••

  • Glendale, California

    RECRUITING

    Glendale, California, 91204, United States

    Contact Email: •••••@•••••

  • Hagerstown, MD

    RECRUITING

    Hagerstown, Maryland, 21740, United States

    Contact Email: •••••@•••••

  • Hagerstown, Maryland

    RECRUITING

    Hagerstown, Maryland, 21740, United States

    Contact Email: •••••@•••••

  • Knoxville, Tennessee

    RECRUITING

    Knoxville, Tennessee, 37922, United States

    Contact Email: •••••@•••••

  • Lemont, IL

    RECRUITING

    Lemont, Illinois, 60439, United States

    Contact Email: •••••@•••••

  • Lemont, Illinois

    RECRUITING

    Lemont, Illinois, 60439, United States

    Contact Email: •••••@•••••

  • Madison, MS

    RECRUITING

    Madison, Mississippi, 39110, United States

    Contact Email: •••••@•••••

  • Madison, Mississippi

    RECRUITING

    Madison, Mississippi, 39110, United States

    Contact Email: •••••@•••••

  • Modesto, California

    RECRUITING

    Modesto, California, 95356, United States

    Contact Email: •••••@•••••

  • Mountain View, California

    RECRUITING

    Mountain View, California, 94040, United States

    Contact Email: •••••@•••••

  • Nashville, TN

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Email: •••••@•••••

  • Nashville, Tennessee

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Email: •••••@•••••

  • Plano, Texas

    RECRUITING

    Plano, Texas, 75075, United States

    Contact Email: •••••@•••••

  • Round Rock, TX

    RECRUITING

    Round Rock, Texas, 78681, United States

    Contact Email: •••••@•••••

  • Round Rock, Texas

    RECRUITING

    Round Rock, Texas, 78781, United States

    Contact Email: •••••@•••••

  • Sacramento, CA

    RECRUITING

    Sacramento, California, 95825, United States

    Contact Email: •••••@•••••

  • Sacramento, California

    RECRUITING

    Sacramento, California, 95841, United States

    Contact Email: •••••@•••••

  • Sactamento, California

    RECRUITING

    Sacramento, California, 95825, United States

    Contact Email: •••••@•••••

  • San Antonio, TX

    RECRUITING

    San Antonio, Texas, 78240, United States

    Contact Email: •••••@•••••

  • San Antonio, Texas

    RECRUITING

    San Antonio, Texas, 78240, United States

    Contact Email: •••••@•••••

  • San Marcos, Texas

    RECRUITING

    San Marcos, Texas, 78666, United States

    Contact Email: •••••@•••••

  • Santa Ana, California

    RECRUITING

    Santa Ana, California, 92705, United States

    Contact Email: •••••@•••••

  • Scottsdale, AZ

    RECRUITING

    Scottsdale, Arizona, 85255, United States

    Contact Email: •••••@•••••

  • Scottsdale, Arizona

    RECRUITING

    Scottsdale, Arizona, 85255, United States

    Contact Email: •••••@•••••

  • The Woodlands, TX

    RECRUITING

    The Woodlands, Texas, 77384, United States

    Contact Email: •••••@•••••

  • The Woodlands, Texas

    RECRUITING

    The Woodlands, Texas, 77384, United States

    Contact Email: •••••@•••••

  • Wake Forest, NC

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

    Contact Email: •••••@•••••

  • Wake Forest, North Carolina

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

    Contact Email: •••••@•••••

  • West Columbia, SC

    RECRUITING

    West Columbia, South Carolina, 29169, United States

    Contact Email: •••••@•••••

  • West Columbia, South Carolina

    RECRUITING

    West Columbia, South Carolina, 29169, United States

    Contact Email: •••••@•••••

  • West Jordan, Utah

    RECRUITING

    West Jordan, Utah, 84088, United States

    Contact Email: •••••@•••••

  • Willow Park, Texas

    RECRUITING

    Willow Park, Texas, 76087, United States

    Contact Email: •••••@•••••

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