Vein disorder

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This early-stage study tests a new drug called EYE201, given as three eye injections over 12 weeks, to see if it is safe and can help reduce swelling in the back of the eye. It includes people with three different eye conditions that cause vision loss: branch retinal vein occlusi…

This phase 3 trial compares two laser wavelengths (1940 nm vs 1470 nm) for closing off faulty veins in people with symptomatic varicose veins. 220 adults will be randomly assigned to one laser or the other. The main goal is to see which laser achieves complete vein closure at 6 m…

This early study tests a new device called the Cook® Venous Valve System in just 4 people with chronic venous insufficiency (leg veins that don't pump blood back to the heart properly). The valve is implanted through a small tube into a deep leg vein to help blood flow one way. T…

This study looks at whether adding targeted laser treatment to the standard ranibizumab injections can help people with macular edema (swelling) from a central retinal vein occlusion need fewer injections over time. About 88 adults with this condition will receive either injectio…

This study tests whether beta-blockers, a type of blood pressure medicine, can reduce the risk of bleeding from small varices in people with cirrhosis and portal hypertension. About 763 adults with small varices will receive either beta-blockers or a placebo for up to 3 years. Th…

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study tests whether a pre-filled syringe is as safe as the traditional vial when giving the medicine bevacizumab for certain eye diseases. About 120 people with wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion will receive inject…

This study looks at whether giving pantoprazole (a stomach acid reducer) after endoscopic treatment for enlarged veins in the esophagus or stomach can lower the chance of bleeding in people with liver cirrhosis. About 208 adults will take part. The goal is to see if short-term us…

This study looks at 70 people with liver cancer who had bleeding from enlarged veins in the esophagus. It compares two procedures—an ultrasound-guided injection of a glue-like substance versus a banding technique—to see which better prevents future bleeding. The goal is to find t…

This study tests a device that uses radiofrequency energy to close off damaged veins in the legs, helping blood flow better and easing symptoms like pain and swelling. About 200 adults with chronic venous insufficiency are taking part. The main goals are to see if the treated vei…

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study tests whether carvedilol, a newer blood pressure drug, works better than the standard drug propranolol for preventing another bleeding episode in people with liver cirrhosis who have already had variceal bleeding. Both drugs are given alongside a procedure to tie off s…

This study tests a one-time procedure to treat a rare brain blood vessel problem called Vein of Galen malformation while the baby is still in the womb. Doctors use a needle through the mother's abdomen and the fetal skull to place tiny coils that block the abnormal blood flow. Th…

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This study tests whether kinesio taping (a special elastic tape) and interval exercise (short bursts of activity) can help people with mild chronic venous insufficiency feel better and improve their quality of life. About 33 adults aged 18 to 65 will be split into three groups: o…

This study is testing a new, less invasive way to perform surgery for grade III hemorrhoids. The goal is to see if using special tools to see and work better inside the body can reduce pain and help people recover faster after surgery. Twenty adults with advanced hemorrhoids will…

This trial tests whether wearing compression stockings with a higher (32 mmHg) or lower (21 mmHg) pressure after radiofrequency ablation for varicose veins leads to less pain and swelling. About 64 adults with varicose veins and leg swelling will wear one of the two stocking type…

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study tests whether using argon plasma coagulation during hemorrhoid surgery can reduce pain and complications compared to standard methods. About 100 adults with severe hemorrhoids will be randomly assigned to one of two surgical techniques. Pain levels and recovery will be…

This study looks at whether adding pelvic floor exercises to a regular exercise program and compression stockings can improve symptoms, blood flow, and quality of life in people with chronic venous insufficiency (a condition where leg veins have trouble sending blood back to the …

This study looks at whether wearing compression stockings for a longer time after foam sclerotherapy (a treatment for varicose veins) can reduce skin darkening (hyperpigmentation) above the treated veins. About 140 adults with varicose veins will be followed for 28 days after the…

This study planned to compare a minimally invasive version of open hemorrhoidectomy to the standard technique in adults with grade III hemorrhoids. The goal was to see if the newer approach causes less pain after surgery. However, the trial was withdrawn before any participants w…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This study aims to create and test a new scoring system called HeQAS that uses a microscope to evaluate the technical quality of hemorrhoid removal surgery. Researchers will check if the score is reliable and whether a newer, less invasive surgical method causes less tissue damag…

This trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The study is small and early-stage, focused on understanding how the device works and whether it is safe. No results are available yet, and the device is not ready for widespread use.

This study looks at how often pelvic congestion syndrome (a condition where veins in the pelvis become enlarged and painful) occurs in women who are about to have a standard procedure for leg varicose veins. Researchers want to know if having this pelvic condition affects how muc…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This study is collecting long-term, real-world data from about 6,000 adults being treated with Roche eye medications (Faricimab or the Port Delivery System with Ranibizumab) for conditions like wet age-related macular degeneration and diabetic macular edema. The goal is to unders…

This study looks at how straining affects people with bleeding hemorrhoids. Researchers will use surveys and a standard test called anorectal manometry to understand the link between pelvic floor problems and hemorrhoid symptoms. The goal is to help doctors give better treatment …

This study follows 100 people with acute deep vein thrombosis in the leg to see how well their vein valves work one year after a clot removal procedure. Participants receive standard care, including a device to remove the clot and blood-thinning medication. The goal is to learn w…

This study looks at 240 adults with liver cirrhosis to learn more about a common complication called portal vein thrombosis (a blood clot in the liver's main vein). Researchers will use ultrasound and CT scans to find clots and track their patterns. The goal is to identify which …

This study looks at data from 100 adults who had hemorrhoid surgery. Researchers will use machine learning to find patterns and group patients by shared traits like age, symptoms, and surgery type. The goal is to see if these groups have different surgical experiences, which coul…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at whether a pneumatic compression device can improve lymphatic function in people with leg swelling from chronic venous disease. 34 participants will be split into two groups: one gets standard compression bandages, the other adds daily pneumatic compression at …