Could ketamine be the key to better pain relief after knee surgery?
NCT ID NCT07059429
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patient-controlled pump. Researchers measured how much opioid painkiller they needed and how much pain they felt in the first 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ketamine
- What this could lead to
- If it works, this could offer a way to reduce opioid use and improve pain control after knee replacement surgery.
- What could go wrong
- This is a small, completed study with no phase designation, so results may not be conclusive or widely applicable. Ketamine can cause side effects like nausea or neuropsychiatric reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pirogov National Medical and Surgical Center
Moscow, 105203, Russia
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Other studies related to the condition(s) this trial covers.
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