OPIOID USE

This study is testing if a smartphone app can help people who use both opioids and cocaine stay in methadone treatment longer and use drugs less often. Participants are randomly assigned to receive either standard methadone treatment or the same treatment plus the app. The app as…

This study is testing whether a handheld device that gently stimulates a nerve in the neck can help people with opioid addiction. Participants stay in a hospital for about a week to see if the device safely reduces withdrawal symptoms and cravings. The goal is to see if this non-…

This study is testing if a smartphone app that gives cash rewards can help people with opioid, cocaine, or methamphetamine addiction stay drug-free. The app tracks participants' progress with at-home drug tests and rewards them with money for clean results. Researchers want to se…

This study is testing a new brain-wave monitor called MGRNOX to see if it helps anesthesiologists use fewer opioid painkillers during surgery. Researchers will compare opioid use in patients having gallbladder surgery, where half the team uses the new monitor for guidance and the…

This study aims to improve access to treatment for opioid addiction in rural Georgia. It connects patients in emergency rooms via video call to addiction specialists who can help start medication. The program also links patients to a recovery coach and local support services to h…

This study is testing a short counseling program designed specifically for people receiving medication treatment for opioid addiction who also drink alcohol. The program aims to help reduce alcohol use, which can increase the risk of overdose and make opioid treatment less effect…

This study tests a community program that helps young people with opioid addiction get treatment faster. The program sends outreach teams to connect youth with medication, counseling, and peer support right away. Researchers want to see if this approach helps young people stay in…

This study tests whether a computer alert system can help doctors prevent opioid overdoses. A machine-learning model identifies patients at high risk, and then the system sends reminders to doctors about safer prescribing practices. The goal is to see if these alerts lead to fewe…

This study aims to see if training people who inject drugs to become peer educators for their social networks can help increase HIV testing and the use of prevention services. The research will involve 360 participants from syringe service programs in Maryland. It will compare a …

This study is testing whether a behavioral therapy that improves sleep can also help reduce pain and lower the use of opioid pain medication. It will involve 165 adults who have chronic pain, trouble sleeping, and are currently prescribed opioids. Researchers believe that by impr…

This study aims to see if using a standard, evidence-based prescription for pain pills after hand or forearm surgery can reduce the number of leftover opioid pills in the community while still providing good pain relief. Researchers will compare this standard prescription to the …

This study is testing if using the Headspace mindfulness app can help women with endometrial or cervical cancer feel less stressed and have a better quality of life during their cancer treatment. Researchers want to see if practicing mindfulness with the app can also help reduce …

This study is testing if a small, non-invasive device placed on the ear can help reduce pain after back surgery. The device gently stimulates nerves to potentially lower pain signals to the brain. Researchers will compare it to a fake device in 20 patients to see if it helps peop…

This study compares two approaches to managing pain after knee surgery: traditional opioid medications versus non-opioid alternatives. Researchers want to see if common non-opioid medications work as well as opioids for pain relief while potentially avoiding opioid risks. The stu…

This study is testing if giving a combination painkiller (Maxigesic) before surgery can reduce the amount of a strong opioid (remifentanil) needed during the operation. Researchers will enroll 96 adults having surgery and use a special monitor to guide precise opioid dosing. The …

This study is testing whether a combination of virtual reality (VR) and pleasant scents can help reduce pain and anxiety for people recovering from major heart or lung surgery. The goal is to see if this drug-free approach can be a practical alternative to strong pain medications…

This study is testing whether a simple numbing injection given around the cervix during vaginal hysterectomy surgery helps patients use fewer strong opioid painkillers afterward. Researchers will compare 56 patients who receive the numbing medicine to those who receive a placebo …

This study is testing a pain management plan that avoids strong opioids for people recovering from clavicle fracture surgery. It will compare this new plan, which uses a combination of common pain relievers, to the standard opioid-based treatment. The goal is to see if the nonopi…

This study is testing a new locked device designed to help patients use opioid pain medications more safely after spine surgery. Thirty patients having a common back operation will be split into two groups: one gets the new smart dispenser that unlocks only at scheduled times via…

This study is testing a personalized pain management system for women after cesarean section. Researchers will use genetic information to try to predict how a mother's body processes pain medication, aiming to provide better pain relief while reducing side effects for both mother…

This study aims to see if a specific type of injection in the back muscles (called an ESPB block) works better than standard skin-level injections at reducing pain and the need for opioid painkillers after lumbar spinal fusion surgery. Researchers will track pain levels and medic…

This study compares two approaches to managing pain after laparoscopic tubal sterilization surgery. Researchers want to see if a combination of non-opioid medications and thorough patient counseling works just as well for pain relief as a standard regimen that includes opioid pil…

This study is testing if giving a single dose of ketamine during surgery helps adults with serious bone injuries recover better. Researchers want to see if ketamine reduces pain after surgery, lowers the need for strong opioid painkillers, and improves symptoms of depression and …

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life for men. It focuses on men with long-term chronic back pain who are taking opioid pain medications and have developed low testosterone as a side e…

This study is testing whether adding pregabalin to lofexidine helps people with opioid addiction better manage withdrawal symptoms when trying to stop using opioids. The trial involves 150 adults who want to start a long-acting medication called naltrexone for their addiction. Pa…

This study is testing if a device called VibraCool can help manage pain and reduce the need for opioid painkillers after ACL reconstruction surgery. Researchers will enroll 130 adults who have had this common knee surgery. They will compare pain levels and opioid use in people us…

This study is testing if applying a steroid directly to the spine during a common back surgery helps patients recover better. Researchers will compare patients who get the steroid to those who get a placebo to see if it reduces pain, shortens hospital stays, helps people return t…

This study is testing if a medication infusion directly into a brain artery can relieve the severe headaches that follow a type of brain bleed called a subarachnoid hemorrhage. Researchers will give 15 patients either lidocaine, lidocaine with a steroid, or no infusion during a s…

This study is testing two different methods to manage pain after total knee replacement surgery. Researchers want to see if using a small, temporary catheter that continuously delivers numbing medicine to the leg is better than a standard single injection at reducing the need for…

This study is comparing two different nerve block techniques to see which one better controls pain and reduces the need for opioid painkillers during and after chest surgery. Researchers will use a special finger monitor to measure patients' pain levels more accurately during the…

This study aims to understand how mindfulness meditation helps reduce chronic low back pain, especially for people taking opioid medications. Researchers will use brain scans and questionnaires to see how meditation changes the brain's response to pain. The goal is to learn more …

This study aims to see if adding a non-addictive pain medication (toradol) to standard opioid painkillers can better manage pain and reduce overall opioid use after a specific leg surgery. It involves 60 adult patients with bone cancer who are having a rod placed in their thigh b…

This study is testing if a small, disposable device that gently stimulates nerves in the ear can help reduce pain and the need for strong opioid painkillers after major abdominal surgery or a liver transplant. Researchers will compare the active device to a placebo version in abo…

This study is testing which of two pain control methods works better for patients having their gallbladder removed through keyhole surgery. It compares a newer nerve-blocking injection (external oblique intercostal block) with the standard method of numbing the small incision sit…

This study aims to understand how long-term opioid use and chronic pain change activity in the brain and spinal cord. Researchers will use MRI scans, questionnaires, and simple tests to compare women with these conditions to healthy women. The goal is to gather knowledge that cou…

This study aims to understand why some people relapse after starting medication treatment for opioid addiction. Researchers will use brain scans on 240 people recently starting treatment to look for patterns linked to staying drug-free. The goal is to learn how the brain changes …