OPIOID USE

This study tests whether having a peer case manager helps people with HIV who also have mental health or substance use problems get the care they need. About 405 participants will be randomly assigned to usual care or to work with a peer who supports them in finding treatment. Th…

This study tests whether giving buprenorphine (a medication for opioid addiction) as a bridge treatment helps people on probation or parole stop using illicit opioids and stay in treatment. About 320 adults in Baltimore will either receive the bridge treatment or be referred to a…

This study looks at the best way to provide HIV prevention medicine (PrEP) and hepatitis C treatment to people who inject drugs. About 446 participants will either get all their care at one location or be referred to a specialist elsewhere. The goal is to see which approach leads…

This study tests a program called TIARAS, which combines a reward system for staying drug-free and on PrEP with expressive writing about past trauma. The goal is to see if this approach helps women who inject drugs reduce their risk of getting HIV. 219 women will take part for 12…

This study looked at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) works as well as opioids for managing pain after wisdom tooth removal. Over 1,800 people took part, rating their pain and satisfaction. The goal is to give doctors bet…

This study looks at whether a numbing injection in the neck (called a cervical block) plus local anesthetic can lower pain, nausea, and the need for strong painkillers after thyroid surgery. About 74 adults having their thyroid removed will be randomly assigned to get either the …

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get a standard or reduced opioid prescription. The goal is t…

This study aimed to see if a laparoscopic-guided nerve block (TAP block) could reduce the need for strong painkillers after weight-loss or stomach surgery. It planned to compare two numbing medicines, but the study was withdrawn before enrolling any participants. No results are a…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for strong painkillers afterward. About 150 adults having certain heart surgeries will get either a long-lasting or standard numbing medicine. The goal is to see which works better for …

This study compares two pain control methods after robotic prostate removal: one using opioids and one using only non-opioid medicines like ketamine, ketorolac, and acetaminophen. About 100 men aged 40-75 with prostate cancer will take part. The goal is to see if the opioid-free …

This study tests a Pain and Coordination Plan (PAC-plan) to reduce opioid use and improve quality of life in adults after accidental injury. About 271 participants will either get the plan or usual care. The plan includes an opioid management schedule, a follow-up doctor visit wi…

This study aimed to create a mobile app to teach people how to safely use, store, and throw away opioid pain medications. Researchers planned to test the app with patients who had a prescription for opioids, but the study was withdrawn before any participants were enrolled. No re…

This study planned to test whether giving methadone during breast reconstruction surgery could reduce the need for other painkillers afterward. It was designed for women having breast reconstruction after mastectomy. However, the study was withdrawn before enrolling any participa…

This study looks at how to better connect people in the court system with medication for opioid use disorder. Researchers will test strategies to help courts quickly screen and link defendants to treatment, with the goal of reducing overdose, addiction, and repeat arrests. About …

This study uses a special imaging scan (PET/CT) with a radioactive tracer to measure inflammation in the brain. Researchers will compare brain inflammation patterns among 26 adults with HIV, opioid use disorder, both, or neither. The goal is to understand how these conditions aff…

This study tracks how patients store and dispose of opioid pain pills after knee or hip replacement surgery. About 163 adults will learn proper storage and disposal methods, then report what they did with unused pills 6-8 weeks later. The goal is to understand how to reduce lefto…