Study tests if common painkillers can replace opioids after surgery

NCT ID NCT04452344

Ongoing Symptom relief Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly assigned to receive either the non-opioid combo or a standard opioid. The goal is to find safer ways to manage acute post-surgical pain and reduce opioid use.

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Conditions

The condition(s) this trial relates to.

agnosia opiate dependence opioid abuse Personal Satisfaction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE

Contacts and locations

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Locations

Rutgers School of Dental Medicine

Newark, New Jersey, 07101, United States
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Rochester

Rochester, New York, 14620, United States

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