OPIOID USE

This trial tests whether a brief psychological intervention—combining education, mindfulness, and acceptance-based strategies—can help people who have had a musculoskeletal injury reduce their opioid use and avoid developing chronic pain. The study enrolls adults admitted to the …

This study tests a brief psychological program designed to help people who have been hospitalized with a musculoskeletal injury and prescribed opioids. The program includes education about long-term opioid use and mindfulness-based strategies, delivered through a computer session…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests a nerve block given during minimally invasive colorectal surgery to see if it reduces pain and the need for opioids. Researchers will track 400 adults having left-sided colon or rectal surgery. The goal is to improve recovery and reduce side effects like nausea.

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to see how the body processes it and what effects it has. The goal is to better understand the potential risks and benefits of krato…

This study looks at how opioid use affects oxidative stress in adults. Researchers will collect blood samples and health information from 120 people taking opioids like morphine or fentanyl. No new treatments are given. The goal is to better understand the biological effects of o…

This study tests whether a special child-resistant blister pack with clear labeling can help reduce how many opioid pills are prescribed and used after orthopedic surgery. About 352 adults will receive either the new packaging or the standard orange bottle. Researchers will track…