Testosterone trial aims to ease opioid side effects in men

NCT ID NCT04798469

Recruiting now Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial is currently recruiting 150 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Testosterone (testosterone undecanoate injection)
What this could lead to: If it works, this could offer a way to ease pain and improve daily life for men on long-term opioids who have low testosterone.
What could go wrong: This is a small Phase 2 trial, so results may not hold up in larger studies. Testosterone therapy also carries risks like prostate issues and blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

eunuchism hypogonadism hypogonadism, male opioid abuse Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGONADISM, MALE OPIOID USE PAIN

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

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