New combo pill aims to calm opioid withdrawal at home
NCT ID NCT05995535
First seen Mar 05, 2026 · Last updated May 08, 2026 · Updated 9 times
Summary
This study tests whether a combination of two medicines, pregabalin and lofexidine, can reduce withdrawal symptoms in people with opioid use disorder who want to start a longer-acting treatment called naltrexone. About 150 adults will receive either the drug combo or a placebo for 8 days while managing withdrawal at home. The goal is to see if the combo makes withdrawal less severe and helps more people successfully start naltrexone.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mountain Manor Treatment Center
NOT_YET_RECRUITINGBaltimore, Maryland, 21229-3618, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania, Treatment Research Center
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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