Could a simple painkiller combo replace strong opioids during surgery?

NCT ID NCT06015711

Recruiting now Symptom relief Sponsor: Ajou University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving patients a combination of ibuprofen and acetaminophen (called Maxigesic) before surgery can reduce the amount of remifentanil, a strong opioid, needed during the operation. The trial will include 96 adults aged 19-60 who are scheduled for surgery under general anesthesia. Researchers will measure how much remifentanil is used and also track painkiller needs after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Maxigesic (a combination of ibuprofen and acetaminophen)
What this could lead to: If it works, this could help reduce opioid use during surgery, potentially lowering side effects and risk of dependence.
What could go wrong: This is a small, early-phase study with only 96 participants, so results may not apply to everyone. The benefit may be small or not seen at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE

Contacts and locations

Locations

Ajou university school of medicine
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea

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