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Nerve block may ease pain and cut opioid use in kids after palate surgery

NCT ID NCT06420336

Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether a quadratus lumborum block—a type of nerve block—can better control pain and reduce opioid use in children aged 6 to 18 who are having palate repair surgery with bone taken from the hip. Half of the participants receive the nerve block, while the other half get standard local anesthetic at the surgical site. Pain scores and medication use are tracked for 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
quadratus lumborum block with ropivacaine and dexamethasone
What this could lead to
If effective, this nerve block could provide better pain control and reduce opioid use in children undergoing palate repair with bone grafting.
What could go wrong
This is a small, early-stage trial. The block may not significantly improve pain or reduce opioid use compared to standard local anesthetic.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 46 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Patients undergoing palatoplasty with autologous bone graft from the anterior iliac crest. * Ages 6-18 years of age * Planned admission post-op * ASA Status Range: 1-3 Exclusion Criteria * Contraindication to QL blocks or LAI which may include: * overlying infection skin at the block needle insertion site * coagulopathies * known bleeding disorders * Allergy to local anesthetic * Cognitive or developmental impairment that would limit ability to report pain. * Non-English Speaking/Writing * Subjects or their parent/guardian unable or choose to not give informed consent/assent.

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Conditions

The condition(s) this trial relates to.

cleft palate opioid abuse Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cleft palate Opioid use Post operative pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

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