CLEFT PALATE
Clinical trials for CLEFT PALATE explained in plain language.
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Can a blood-derived patch strengthen cleft palate repair?
Disease control Recruiting nowThis trial compares standard cleft palate surgery alone versus surgery augmented with platelet-rich fibrin (PRF) or gentamicin-loaded PRF in 90 children and adolescents with cleft palates. The goal is to see if these biological adjuncts improve wound healing, reduce wound breakdo…
Matched conditions: CLEFT PALATE
Phase: NA • Sponsor: Al-Thawra Modern General Hospital • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Nerve block may ease pain and cut opioid use in kids after palate surgery
Symptom relief Recruiting nowThis study tests whether a quadratus lumborum block—a type of nerve block—can better control pain and reduce opioid use in children aged 6 to 18 who are having palate repair surgery with bone taken from the hip. Half of the participants receive the nerve block, while the other ha…
Matched conditions: CLEFT PALATE
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated Jul 11, 2026 00:00 UTC
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Could skipping opioids make Kids' cleft surgery safer?
Symptom relief Recruiting nowThis study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …
Matched conditions: CLEFT PALATE
Phase: NA • Sponsor: Iva Smiljanić • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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New study tests methadone for safer pain relief in kids after cleft palate surgery
Symptom relief Recruiting nowThis study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …
Matched conditions: CLEFT PALATE
Phase: PHASE4 • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Can a simple painkiller boost drinking after palate repair?
Symptom relief Recruiting nowThis study tests whether adding a pain medicine called Ketorolac to standard care helps children drink more fluids after cleft palate surgery. About 74 children with cleft palate (with or without cleft lip) will take part. The goal is to see if better pain control leads to improv…
Matched conditions: CLEFT PALATE
Phase: PHASE4 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Which sedative works best for kids after cleft surgery? new study aims to find out
Symptom relief Recruiting nowThis study compares three different sedatives (ketamine, nalbuphine, and dexmedetomidine) given to 60 children aged 6 months to 3 years who need stitches removed after cleft lip or palate surgery. The goal is to see which drug works fastest and safest to keep the child calm and c…
Matched conditions: CLEFT PALATE
Phase: NA • Sponsor: University Medical Centre Ljubljana • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Could a simple mist replace needles for kids' post-surgery pain?
Symptom relief Recruiting nowThis study tests whether giving a numbing medicine (bupivacaine) as a mist before surgery can lower pain and the need for extra painkillers in children aged 1-7 having cleft palate repair. Half the children get the mist, half get a placebo, and neither the doctors nor families kn…
Matched conditions: CLEFT PALATE
Phase: PHASE3 • Sponsor: Assiut University • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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MRI scans reveal hidden causes of speech issues in cleft palate kids
Knowledge-focused Recruiting nowThis study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…
Matched conditions: CLEFT PALATE
Phase: NA • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC