Could oxygen or a common drug fix Opioid-Linked sleep apnea?

NCT ID NCT05589753

Recruiting now Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to treat sleep-disordered breathing linked to opioid use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oxygen and acetazolamide
What this could lead to: If successful, this could point toward new, non-opioid treatments for sleep apnea in people who rely on opioid medications, potentially improving sleep and overall health.
What could go wrong: This is an early-phase study with a small number of participants, so results may not apply to everyone. Acetazolamide can cause side effects like tingling, nausea, or electrolyte imbalances.

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Conditions

The condition(s) this trial relates to.

opioid abuse sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE SLEEP APNEA SLEEP DISORDERED BREATHING

Contacts and locations

Locations

John D. Dingell VA Medical Center, Detroit, MI
RECRUITING

Detroit, Michigan, 48201-1916, United States

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