SLEEP APNEA

This study tracks 225 adults with moderate to severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulator. The device is implanted and stimulates a nerve to keep the airway open during sleep. The goal is to see how well it reduces breathing pauses and how …

This study tests a new device called the Lunair Alpha System for people with moderate to severe sleep disordered breathing who cannot use standard treatments like CPAP machines. The device is implanted and uses nerve stimulation to improve breathing during sleep. The trial will c…

This study tests a new device called the remedē Dual Channel System for people with severe sleep apnea. The device is implanted in the body to help keep breathing steady during sleep. The study will check if the implant is safe and works well in 40 adults over 12 months.

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with a new sleep apnea diagnosis. The goal is to see if raising …

This study looks at ways to treat sleep-disordered breathing in adults with chronic cervical spinal cord injury (more than 6 months after injury). Researchers will measure changes in breathing, sleep apnea severity, and other breathing control signals. The goal is to find effecti…

This study tests whether breathing air with slightly higher carbon dioxide (hypercapnia) for two weeks can improve breathing and reduce sleep apnea in veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will tak…

This study tests if bexagliflozin, a diabetes drug, can reduce the severity of sleep apnea in overweight or obese adults with moderate to severe obstructive sleep apnea. Over 6 months, participants take either the drug or a placebo and undergo sleep tests and body scans to measur…

This study looks at whether oxygen, finasteride, or acetazolamide can help reduce sleep apnea in people aged 60 and older with mild to moderate sleep apnea. The goal is to find new ways to stabilize breathing and improve sleep. About 100 elderly Veterans will take part to see whi…

This study will follow 1,000 adults with suspected sleep apnea to learn more about their condition, daytime sleepiness, and quality of life. Participants will undergo sleep tests, blood pressure monitoring, and complete questionnaires. Researchers will track how well patients sti…

This study looks at whether a daytime sleep test works as well as an overnight one for adjusting the Inspire device, which treats obstructive sleep apnea. About 110 adults who already have the Inspire implant will take part. The goal is to see if daytime testing can save time and…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep, which can affect how well a brain shunt works. Researchers will measure these pressures in 30 adults with normal-pressure hydrocephalus to decide if the shunt should drain fluid into the bel…