Sleep apnea study tests pill to boost CPAP use and brain power

NCT ID NCT07332442

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo for three months while using CPAP. Researchers will track how often participants use CPAP and measure changes in attention and daytime sleepiness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eszopiclone (a sleep medication)
What this could lead to: If it works, this could point toward a way to help people with sleep apnea stick with CPAP therapy and possibly improve their thinking and daytime alertness.
What could go wrong: This is a Phase 3 trial, but it's still testing a hypothesis. The sleep aid may not improve CPAP use or thinking, and could cause side effects like drowsiness or dizziness.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA SLEEP APNEA

Contacts and locations

Locations

Yale Centers for Sleep Medicine
RECRUITING

North Haven, Connecticut, 06347, United States

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