Could a neck device curb opioid withdrawal?
NCT ID NCT05834478
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain scans. The goal is to see if the device makes withdrawal less severe and helps people stick with treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcutaneous cervical vagal nerve stimulation (tcVNS) device
What this could lead to
If it works, this could offer a drug-free way to reduce opioid withdrawal symptoms and help people stay in treatment.
What could go wrong
This is still a small, early-phase trial with only 103 participants, and the device may not work better than a sham. The study also requires an inpatient stay and MRI, which may limit who can take part.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OPIOID USE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
12 Executive Park Drive
RECRUITINGAtlanta, Georgia, 30329, United States
-
Emory University
RECRUITINGAtlanta, Georgia, 30329, United States
-
Emory University Clinical Research Network
RECRUITINGAtlanta, Georgia, 30322, United States
-
Georgia Institute of Technology
RECRUITINGAtlanta, Georgia, 30332, United States
-
Health Sciences Research Building
NOT_YET_RECRUITINGAtlanta, Georgia, 30322, United States
-
Rollins School of Public Health
RECRUITINGAtlanta, Georgia, 30322, United States