Cash for clean tests: App-Based rewards aim to curb opioid and cocaine use

NCT ID NCT04927143

Recruiting now Disease control Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating rewards for clean tests, while a control group gets no rewards. The goal is to find the best way to design these incentives to encourage long-term abstinence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: financial incentives via smartphone app
What this could lead to: If successful, this could provide a low-cost, scalable way to help people with substance use disorders achieve and maintain abstinence.
What could go wrong: This is a behavioral study, not a drug trial. The effect may be modest, and long-term abstinence after incentives stop is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amphetamine abuse cocaine abuse cocaine dependence methamphetamine dependence opiate dependence opioid abuse substance abuse substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COCAINE USE COCAINE USE DISORDER METHAMPHETAMINE ABUSE METHAMPHETAMINE-DEPENDENCE OPIOID USE OPIOID-USE DISORDER SUBSTANCE USE

Contacts and locations

Locations

Advocate Aurora Behavioral Health Services
RECRUITING

Wauwatosa, Wisconsin, 53212, United States
Rogers Behavioral Health
RECRUITING

Oconomowoc, Wisconsin, 53066, United States

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