METHAMPHETAMINE ABUSE

This study tests a new medicine called CS-1103 in 40 healthy adults who use methamphetamine but are not looking for treatment. Participants get a single dose of methamphetamine along with CS-1103 to see if the drug can safely reduce meth's effects and help the body get rid of it …

This study tests two ways of giving rewards to encourage people with opioid or cocaine use disorder to stay drug-free. 600 adults will use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to see which approach h…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study tests whether a combination of two medications (extended-release naltrexone and bupropion) can help people with moderate to severe methamphetamine use disorder reduce their drug use. The study will enroll 360 adults who want to stop or cut down on meth. Participants wi…

This study tests whether ketamine, given through an IV, can help adults with moderate to severe methamphetamine use disorder reduce or stop their use. 120 participants will receive either ketamine or a placebo drug, and researchers will check urine samples to see if the treatment…

This study tests whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks helps people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 adults who completed a prior trial will receive either the drug or a pla…

This study looks at whether recalling a positive memory can improve mood and decision-making in 80 adults with methamphetamine use disorder who are in treatment. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral one. The g…