Experimental drug aims to curb meth high in small trial

NCT ID NCT06721494

Recruiting now Disease control Sponsor: Clear Scientific, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 08, 2026 · Updated 4 times

Summary

This study tests an experimental drug called CS-1103 in 40 healthy adults with methamphetamine use disorder who are not seeking treatment. Participants receive a single dose of methamphetamine along with CS-1103 to see if the drug can safely reduce the effects of intoxication. The main goal is to check for side effects and how the drug works in the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CS-1103 (an experimental drug given intravenously)
What this could lead to: If successful, this could point toward a treatment to reduce the effects of methamphetamine intoxication and help manage use disorder.
What could go wrong: This is an early Phase 2 trial with only 40 participants, so results may not apply broadly. The drug is given alongside methamphetamine, and safety is the main focus.

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Conditions

The condition(s) this trial relates to.

amphetamine abuse methamphetamine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METHAMPHETAMINE ABUSE METHAMPHETAMINE DISORDERS METHAMPHETAMINE INTOXICATION

Contacts and locations

Locations

California Clinical Trials Medical Group
RECRUITING

Glendale, California, 91206, United States

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