SUBSTANCE USE

This study tests two ways of giving rewards to encourage people with opioid or cocaine use disorder to stay drug-free. 600 adults will use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to see which approach h…

This study tests two programs for people recently in jail or under supervision. One offers health navigation; the other adds employment help and small financial incentives. The goal is to see which better helps participants access HIV care, prevention, and jobs. About 350 Black m…

This study is testing a 6-month behavioral health program for 200 people who either have HIV or are seeking HIV prevention. The program includes counseling, peer support, and education tailored to each person's needs. Researchers want to see if it helps reduce depression, anxiety…

This study tests whether a peer-led program combining acceptance and commitment therapy, exercise, and social support can help women living with HIV improve their medication adherence. The program also addresses substance use, trauma, and violence. Researchers will enroll 300 wom…

This study looks at whether taking part in a traditional Ojibwe ceremony called Gii'igoshimong can help American Indian adults cut down on substance use and improve their mental health. About 300 adults who identify as Ojibwe and have used substances in the past month will be ran…

This study tests whether ketamine, given through an IV, can help adults with moderate to severe methamphetamine use disorder reduce or stop their use. 120 participants will receive either ketamine or a placebo drug, and researchers will check urine samples to see if the treatment…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the urge to drink alcohol and lower heavy drinking days. About 86 adults with alcohol use disorder will receive either real or sham TBS over the front part of …

This study tests whether trained peer supporters can help Black adults with HIV or at high risk stay on track with long-acting injectable HIV medication (PrEP/ART) and cut down on substance use. About 186 participants will receive either peer-led coaching or standard care. The go…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for or living with HIV and also have substance use issues. The program provides support to start HIV prevention medicine (PrEP) or to lower the amount of virus in the body for those alread…

This study tests a program called Hastiin Bidziil (Strong Man) to help Native American men reduce their use of alcohol and drugs. About 160 men aged 18 and older who live near Fort Defiance or Chinle, Arizona will take part. The program uses cultural strengths to support recovery…

This study is testing a special harm reduction service designed for transgender women, men, and non-binary people in Thailand who use substances or engage in chemsex. The goal is to increase use of HIV prevention pills (PrEP), reduce sexually transmitted infections, and improve m…

This study tests if a program called Bright Horizons can help prevent binge drinking and drug use in Native American teens aged 12-17. The program teaches skills like managing emotions, coping with stress, and setting goals. Researchers will track changes in alcohol use over 30 d…

This study is testing an after-school program called Native Spirit for American Indian teens in grades 7-12. The program uses cultural activities to strengthen identity, self-esteem, and resilience, with the goal of preventing substance use. About 60 participants from two Arizona…

This study is testing whether a smartphone app called Pink Cloud can help people recovering from alcohol or drug use stay sober and have fewer problems related to substance use. About 1,410 adults in recovery will be randomly assigned to use the app or not, and researchers will c…

This study tests a brief computer program designed to help teenagers aged 13 to 17 reduce their use of cannabis and alcohol. Participants who are already seeking treatment for substance use will use the program and then be followed up at one and three months. The goal is to see i…

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study tests a program called Family Spirit Strengths to help American Indian and Alaska Native mothers and caregivers manage depression, anxiety, and substance use. About 188 pregnant women or caregivers of young children who have mental health symptoms will take part. Half …

This study tests a peer-led program called PEGISUS that aims to reduce substance use and promote fair gender attitudes among young people in vocational training in Zambia, Zimbabwe, and South Africa. About 264 participants aged 16-24 who use alcohol or drugs at least weekly will …

This study aims to improve alcohol and drug treatment for Black teenagers on probation by making it more culturally relevant. Researchers will interview teens and hold focus groups with parents and community advocates to understand how racial discrimination affects substance use.…

This study looks at whether harm reduction care—where healthcare providers focus on reducing harm rather than judging drug use—can improve health outcomes and reduce stigma for people living with HIV who use drugs. Researchers will study about 768 patients and their providers at …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1,800 veterans who recently left service and have a back, neck, knee, or shoulder condition will take part. The program includes s…

This study talks to men who have sex with men and take part in chemsex (using drugs during sex) in Bangkok. Researchers want to learn about the risks, health problems, and needs of these men. The goal is to create a program where party hosts help reduce harm, like preventing HIV …

This study looks at whether adding conversations about sexual pleasure to existing harm reduction services helps men who have sex with men and transgender people who use drugs during sex. Researchers will use a tool called the Pleasuremeter to measure sexual pleasure and see how …

This study aims to understand the health and well-being of university students and employees by tracking factors like loneliness, anxiety, stress, and health habits. About 363 participants will fill out surveys and may take part in interviews. No treatment or medication is involv…

This study looks at whether offering extra support to fathers can improve the well-being of children in families where substance misuse is a concern. About 240 fathers in the Bronx and nearby areas will be randomly assigned to either standard services or an enhanced program that …

This study tests a program called iDECIDE, which teaches middle and high school students about drugs and their effects as an alternative to punishment for breaking school substance policies. About 300 students who recently violated these rules will be randomly assigned to either …

This study talks to transgender people about their experiences with chemsex (using drugs during sex) to learn why they do it, the good and bad effects, and what kind of help they need. Researchers will also ask healthcare workers and community leaders about barriers to providing …

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 will have a brain scan and then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study is creating and testing a 12-week educational program for Black adults aged 18-35 who have experienced trauma and substance use. The program teaches about mental health, reduces stigma, and encourages seeking help. Researchers will check if it improves knowledge and at…

This study looks at how personality, brain activity, and behavior differ among young adults aged 18-22. Researchers want to see if certain patterns of attention and reward processing are linked to cannabis use. Participants will complete tasks and brain scans. The goal is to bett…

This study compares two approaches to address alcohol and drug use in teens during primary care visits: one that only involves the teen, and another that includes their family. Researchers will follow 2,300 teens and their caregivers for one year to see which method works better.…