SUBSTANCE USE

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a program called Hastiin Bidziil (Strong Man) to help Native American men ages 18 and older reduce their use of alcohol and drugs. About 160 men from Arizona communities will take part. The program focuses on cultural strengths and community support to lower subs…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This study looks at whether taking part in a traditional Ojibwe ceremony called Gii'igoshimong can help American Indian adults cut down on substance use and improve their mental health. About 300 adults who identify as Ojibwe/Anishinaabe/Chippewa and have used substances in the p…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This trial tests a peer-led program called PEGISUS to reduce substance use and promote fair gender beliefs among 264 young people (ages 16-24) in vocational training in Zambia, Zimbabwe, and South Africa. Participants in peer groups will attend eight sessions, while a control gro…

This study is testing whether a mobile app called Pink Cloud can help people recovering from drug or alcohol problems stay sober. Over 1,400 adults who have completed treatment will use the app for a year, which includes a meeting finder, sobriety tracker, and planning tools. Res…

This study tests whether a program called Bright Horizons can help prevent binge drinking and drug use in Native American youth aged 10 to 24. The program teaches skills like managing emotions, coping with stress, and setting goals. Researchers will compare it to standard case ma…

This study aims to create and test a prevention program for e-cigarette use among 6th-8th graders in rural Hawaii. The program includes classroom lessons, social media content, and a print campaign, all designed with Hawaiian culture in mind. Researchers will work with 500 studen…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study tests a support service designed specifically for transgender women, men, and non-binary people in Thailand who have used chemsex drugs or other substances in the past year. The program offers HIV prevention (PrEP), mental health support, and STI care. Researchers will…

This study tests an after-school program called Native Spirit for Indigenous teens in grades 7-12. The program uses cultural activities to strengthen identity, self-esteem, and resilience, with the goal of preventing substance use. About 60 teens from two Arizona tribes will take…

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at how differences in personality, brain activity, and behavior may make some young adults more likely to use substances like cannabis. Researchers will track eye movements and brain scans in 294 people aged 18-22. No treatment or medication is involved—the goal …

This study is testing a program called Project REACH, which offers telehealth services at syringe service programs (places where people can get clean needles). The goal is to see if this makes it easier for people who use drugs to get HIV prevention (like PrEP) and addiction trea…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study tests a 10-week parenting program called Parenting in 2 Worlds (P2W), designed specifically for urban American Indian families. Researchers will compare it to a general health program in four U.S. cities with 1,440 parent-teen pairs. The goal is to see if P2W improves …

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study tests whether adding a tool called the Pleasuremeter to standard harm reduction services helps men who have sex with men and transgender people who use drugs or engage in chemsex talk about and improve their sexual pleasure. The goal is to see if people are willing to …

This study interviews 50 transgender adults in Thailand about their chemsex behaviors—reasons, patterns, and impacts—along with stigma and HIV prevention needs. Researchers also gather input from stakeholders to identify barriers and facilitators for creating transgender-friendly…

This study is gathering information from men who have sex with men who take part in chemsex (using drugs before or during sex) in Bangkok, Thailand. Researchers will survey party hosts and guests about their drug use, sexual health, mental health, and experiences of stigma. The g…

This study looks at whether special programs for fathers can help families in the Bronx and nearby areas who are at risk for substance misuse. About 240 fathers will be randomly assigned to either get usual services or extra support like counseling, fatherhood classes, and case m…

This study compares two approaches to screening and counseling teens about alcohol and drug use during primary care visits. One approach involves only the teen, while the other includes the whole family. Researchers will follow 2,300 teens and their caregivers for one year to see…

This study works with Black teens on probation and their families to adapt alcohol and drug treatment to better address experiences of racial discrimination. Researchers will interview teens and hold focus groups with parents and community advocates to learn what works. The goal …

This study tests a 4-session drug education program called iDECIDE for middle and high school students who recently violated their school's substance use policy. About 300 students will be randomly assigned to either take the program right away or wait. Researchers will measure c…