SUBSTANCE USE
Clinical trials for SUBSTANCE USE explained in plain language.
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Bringing prenatal care to the community: ultrasound and support for moms with substance use
Disease control CompletedThis study tested a program that brings fetal ultrasound and care coordination directly into the community for pregnant women with substance use disorder. The goal was to help them attend more prenatal visits and substance use treatment sessions. 103 pregnant women participated, …
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Disease control
Last updated May 16, 2026 23:48 UTC
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New study tests better ways to link former inmates to HIV and addiction treatment
Disease control CompletedThis study looked at two different methods to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults who had been involved with the justice system in the last 6 months and had a history of opioi…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Yale University • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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Texts and telehealth show promise for HIV care in youth
Disease control CompletedThis study tested whether a problem-solving program delivered by video calls and text messages could help young people aged 18-29 living with HIV stay engaged in care, improve mental health, and reduce substance use. Fifty participants from the East Bay area of San Francisco took…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 12, 2026 13:40 UTC
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Can teens help prevent opioid abuse? new study says maybe
Prevention CompletedThis pilot study tested whether getting young people actively involved in prevention programs can reduce substance misuse. Four community organizations in North Carolina took part; some used a youth engagement strategy while others did not. Researchers surveyed staff and youth to…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Prevention
Last updated May 16, 2026 23:48 UTC
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New program aims to curb risky drinking and drug use in young adults
Prevention CompletedThis study tested whether a new personalized feedback program helps young adults aged 18-25 reduce risky alcohol and drug use. 660 participants from across the US took part. The program provided tailored information to encourage healthier choices and reduce substance-related prob…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Rutgers, The State University of New Jersey • Aim: Prevention
Last updated May 14, 2026 12:04 UTC
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Couples-Focused program boosts HIV prevention and cuts stigma in cape town
Prevention CompletedThis study tested a program called Couples Health CoOp Plus for young couples (ages 18-30) in Cape Town who use alcohol or drugs. The goal was to help them start and stick with HIV prevention (PrEP) or treatment (ART), reduce risky behaviors, and lower stigma in their communities…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: RTI International • Aim: Prevention
Last updated May 14, 2026 12:01 UTC
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Housing first: a bold experiment to stop opioid addiction before it starts
Prevention CompletedThis study tested whether providing housing along with opioid prevention services can stop homeless youth (ages 18-24) from developing opioid use disorder. Researchers tracked 240 participants for a year, measuring how often they used opioids. The goal was to see if stable housin…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Ohio State University • Aim: Prevention
Last updated May 13, 2026 16:03 UTC
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New program aims to keep at-risk teens off opioids
Prevention CompletedThis study tested a program called Trust-based Relational Intervention (TBRI) to prevent opioid and other drug use in 250 teens aged 15-18 who were involved in the juvenile justice system. The program trained a trusted adult to support each teen as they transitioned back into the…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Texas Christian University • Aim: Prevention
Last updated Apr 29, 2026 15:04 UTC
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Can online mindfulness beat COVID-19 depression?
Symptom relief CompletedThis study tested three remote programs to help people with depression and substance use caused by COVID-19 stress. 113 adults from Cambridge Health Alliance took part. They either joined an 8-week online mindfulness class, an online therapy program, or received standard remote m…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Cambridge Health Alliance • Aim: Symptom relief
Last updated May 16, 2026 23:48 UTC
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Online resilience training shows promise for pain and substance use
Symptom relief CompletedThis small pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 online video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and he…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Jafar Bakhshaie • Aim: Symptom relief
Last updated May 16, 2026 23:37 UTC
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Talking therapy curbs opioid risk in cancer patients
Symptom relief CompletedThis study tested a 6-session counseling program called ACT for Cancer to help cancer patients avoid misusing opioid pain medications. The program focuses on managing difficult thoughts and feelings without turning to opioids. 40 adults with cancer who were at risk for opioid mis…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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AI tool aims to catch hidden substance abuse in hospitals
Knowledge-focused CompletedThis study developed a computer program that scans hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling or treatment to t…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated May 16, 2026 23:50 UTC
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Smart pill boosts HIV prevention in men with substance use
Knowledge-focused CompletedThis study tested a special digital pill that sends a signal when taken, along with a phone app, to help HIV-negative men who have sex with men and struggle with substance use stick to their daily HIV prevention medication (PrEP). Forty participants took the digital pill for 60 d…
Matched conditions: SUBSTANCE USE
Phase: PHASE3 • Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated May 16, 2026 23:37 UTC
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New Spanish-Language screening tool tested for substance use in clinics
Knowledge-focused CompletedThis study tested a Spanish-language electronic tool called TAPS-ESP to see if it can accurately screen for tobacco, alcohol, prescription drug misuse, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic took the screening, and their resul…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated May 16, 2026 23:36 UTC
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New study tests best ways to help At-Risk native youth
Knowledge-focused CompletedThis study looked at which combinations of support programs—New Hope, Elders Resilience, and Case Management—work best to reduce suicidal thoughts and build resilience in American Indian youth ages 10-29 who are at risk for suicide. Researchers tested different sequences of these…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Johns Hopkins Bloomberg School of Public Health • Aim: Knowledge-focused
Last updated May 15, 2026 11:56 UTC
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Trusted messengers boost COVID testing in opioid users
Knowledge-focused CompletedThis study tested two ways to get people who use opioids to take a COVID-19 test: having friends refer them, or having trained community members reach out directly. About 500 adults who had used opioids in the past 6 months took part. The goal was to see which method worked bette…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: New York State Psychiatric Institute • Aim: Knowledge-focused
Last updated May 15, 2026 11:56 UTC
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Can peers help teens with psychosis quit drugs? new study says maybe.
Knowledge-focused CompletedThis study tested a program called PAS-EPP, where trained peer supporters help young people with early psychosis reduce or stop using alcohol and drugs. About 113 participants from coordinated specialty care teams took part. The goal was to see if the program is practical and acc…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Stigma-Busting study: can training doctors change minds?
Knowledge-focused CompletedThis study tested whether a special anti-stigma program for healthcare workers improves their attitudes toward people with mental health or substance use problems. About 485 staff and clients from six health centers took part—three centers got the program, three did not. Research…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC
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Can video chats help families cope with psychosis and addiction?
Knowledge-focused CompletedThis study tested a telehealth program called CRAFT-EP that helps families support a relative with early psychosis and substance use (like alcohol or cannabis). 65 family members took part. The goal was to see if the program improves family wellbeing, including depression and anx…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated May 11, 2026 20:41 UTC
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New program aims to break the cycle of prison for traumatized youth
Knowledge-focused CompletedThis study tested a program called RISE for young men leaving prison. The program provides trauma counseling and help finding a job and housing. Researchers wanted to see if this support would improve their mental health and stability, and lower the chance they would go back to p…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Florida State University • Aim: Knowledge-focused
Last updated May 07, 2026 18:38 UTC
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New guide aims to help agencies tackle opioid crisis and child welfare
Knowledge-focused CompletedThis study looked at how to help child welfare agencies work better with families affected by substance use. Researchers worked with 9 professionals to create and test a guide that helps agencies choose the best strategies for supporting these families. The goal was to see if the…
Matched conditions: SUBSTANCE USE
Phase: NA • Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated May 04, 2026 16:22 UTC