Neck surgery aims to drain Alzheimer's brain waste

NCT ID NCT07073066

Recruiting now Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a surgical procedure called deep cervical lymphatic venous anastomosis (DC-LVA) in 376 people with moderate-to-severe Alzheimer's disease. The surgery connects lymph vessels in the neck to veins, aiming to improve drainage of waste from the brain. Researchers will compare cognitive decline over 12 months between those who get the surgery plus usual care and those who receive usual care alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep cervical lymphatic venous anastomosis (DC-LVA) surgery
What this could lead to: If it works, this surgery could slow cognitive decline in moderate-to-severe Alzheimer's disease by improving the brain's waste drainage.
What could go wrong: This is an early-stage surgical procedure with unknown long-term safety and efficacy. The trial is open-label, so both patients and doctors know who got the surgery, which can bias results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMERS DISEASE

Contacts and locations

Locations

Beijing Tiantan Hopital, Capital Medical University
RECRUITING

Beijing, 100070, China
Dongguan Chashan Hospital
RECRUITING

Dongguan, Guangdong, China
First Affiliated Hospital of Shandong First Medical University
ACTIVE_NOT_RECRUITING

Jinan, Shandong, 250000, China
Guangdong Second People's Hospital
RECRUITING

Guangdong, Guangzhou, 510000, China
Jining First People's Hospital
RECRUITING

Jining, Shandong, 272000, China
Shandong Provincial Public Health Clinical Center
RECRUITING

Jinan, Shandong, 250000, China
Shandong Provincial Third Hospital
RECRUITING

Jinan, Shandong, 250000, China
The First Affiliated Hospital of Ningbo University
RECRUITING

Ningbo, Zhejiang, 315000, China
Zhengzhou Central Hospital
RECRUITING

Zhengzhou, Henan, 450000, China

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