Neck surgery aims to drain Alzheimer's brain waste
NCT ID NCT07073066
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a surgical procedure called deep cervical lymphatic venous anastomosis (DC-LVA) in 376 people with moderate-to-severe Alzheimer's disease. The surgery connects lymph vessels in the neck to veins, aiming to improve drainage of waste from the brain. Researchers will compare cognitive decline over 12 months between those who get the surgery plus usual care and those who receive usual care alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deep cervical lymphatic venous anastomosis (DC-LVA) surgery
What this could lead to
If it works, this surgery could slow cognitive decline in moderate-to-severe Alzheimer's disease by improving the brain's waste drainage.
What could go wrong
This is an early-stage surgical procedure with unknown long-term safety and efficacy. The trial is open-label, so both patients and doctors know who got the surgery, which can bias results.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Tiantan Hopital, Capital Medical University
RECRUITINGBeijing, 100070, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Dongguan Chashan Hospital
RECRUITINGDongguan, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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First Affiliated Hospital of Shandong First Medical University
ACTIVE_NOT_RECRUITINGJinan, Shandong, 250000, China
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Guangdong Second People's Hospital
RECRUITINGGuangdong, Guangzhou, 510000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jining First People's Hospital
RECRUITINGJining, Shandong, 272000, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
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Shandong Provincial Public Health Clinical Center
RECRUITINGJinan, Shandong, 250000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Provincial Third Hospital
RECRUITINGJinan, Shandong, 250000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The First Affiliated Hospital of Ningbo University
RECRUITINGNingbo, Zhejiang, 315000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Zhengzhou Central Hospital
RECRUITINGZhengzhou, Henan, 450000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••