Could Pre-Surgery proton beams boost brain tumor outcomes?

NCT ID NCT07710040

Recruiting now Disease control Sponsor: National Medical Research Radiological Centre of the Ministry of Health of Russia Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This trial investigates whether giving a short course of targeted proton radiation before surgery is safe for people with high-grade gliomas, an aggressive type of brain tumor. Nine participants will receive one of three escalating doses of proton therapy, followed by standard surgery and chemoradiotherapy. The goal is to find the highest safe dose and see if this approach improves tumor removal and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: preoperative proton stereotactic radiotherapy
What this could lead to: If successful, this approach could improve tumor control and survival for patients with high-grade gliomas by combining targeted radiation before surgery with standard treatment.
What could go wrong: This is a very early phase 1 trial with only 9 participants, so the safety and effectiveness are not yet established. There is a risk of radiation-induced toxicity, and the study may be stopped if unacceptable side effects occur.

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Conditions

The condition(s) this trial relates to.

malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMAS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Proton Therapy Department, A. Tsyb Medical Radiological Research Center - branch of the National Medical Radiological Research Center
RECRUITING

Obninsk, Kaluga Oblast, 249036, Russia

Contact Phone: •••-•••-•••• Email: •••••@•••••

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