Could a special antibiotic implant stop bone infections after bad breaks?
NCT ID NCT05766670
First seen Oct 31, 2025 · Last updated May 11, 2026 · Updated 29 times
Summary
This study tests whether placing an antibiotic-coated material inside the bone during surgery can prevent infections after severe open fractures of the shinbone. About 497 adults with serious open fractures will be randomly assigned to get either the antibiotic depot plus standard care, or standard care alone. The main goal is to see if the depot reduces deep infections within a year.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Atrium Health Cabarrus
RECRUITINGConcord, North Carolina, 28025, United States
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Atrium Health Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28204, United States
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Atrium Health Navicent The Medical Center
RECRUITINGMacon, Georgia, 31201, United States
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Atrium Health Wake Forest Baptist Medical Center
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Cedars-Sinai
RECRUITINGLos Angeles, California, 90048, United States
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Louisiana State University Health Sciences Center
RECRUITINGNew Orleans, Louisiana, 70112, United States
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Pennsylvania State University
RECRUITINGHershey, Pennsylvania, 17033, United States
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University of Kentucky
NOT_YET_RECRUITINGLexington, Kentucky, 40508, United States
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Valley Health
RECRUITINGWinchester, Virginia, 22601, United States
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
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