Could a common blood pressure pill ease PTSD nightmares in veterans?

NCT ID NCT04877093

Recruiting now Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low dose of clonidine, a drug usually used for high blood pressure, can improve sleep and reduce PTSD symptoms in veterans. About 32 veterans with PTSD will take a flexible dose of clonidine nightly for 6 weeks. Researchers will track changes in sleep quality, PTSD severity, and mood using questionnaires and sleep diaries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clonidine pill (low dose)
What this could lead to: If it works, this could offer a simple, low-cost option to help veterans with PTSD sleep better and feel less distressed.
What could go wrong: This is a small early-phase trial with only 32 participants, so results may not apply to all veterans. Clonidine can cause side effects like low blood pressure and drowsiness.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTTRAUMATIC STRESS DISORDER PTSD SLEEP

Contacts and locations

Locations

Aurora Psychiatric Hospital
RECRUITING

Wauwatosa, Wisconsin, 53213, United States

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