POSTTRAUMATIC STRESS DISORDER

This study tests a digital program designed to prevent posttraumatic stress disorder (PTSD) and cannabis use disorder in women who have been sexually assaulted. The program targets anxiety sensitivity, a known risk factor. Researchers will enroll 68 women who come to the emergenc…

This study tests whether a brief form of exposure therapy, given soon after a serious injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 adults admitted to Level I trauma centers. Participants will be randomly assigned to receive the brief thera…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both PTSD and substance use disorders. Participants will complete five writing sessions about their trauma. The goal is to see if this approach reduces PTSD symptoms …

This study compares two intensive formats of cognitive behavioral therapy for veterans with PTSD and anxiety disorders. About 306 veterans will receive either individual therapy over two weeks, group therapy over two days, or usual care. The goal is to see which format best reduc…

This study tests whether a stepped care approach using complementary health treatments (like mind-body therapies) can help people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researc…

This study looks at older adults (50+) with PTSD and ongoing insomnia. After a talk therapy for PTSD, those with remaining sleep issues will get a non-drug sleep program. Researchers will check if this improves sleep, PTSD symptoms, heart health markers like blood pressure, and q…

This study tests whether a therapy that combines PTSD treatment with alcohol relapse prevention works better than alcohol treatment alone. 200 adults with both PTSD and alcohol use disorder will receive either the combined therapy or standard alcohol-focused therapy. Researchers …

This early-stage study tests whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in 40 military veterans. Participants will be closely monitored for side effects and changes in PTSD severity. The goal is to gather initial safety data and see…

This study tests if a nerve block (stellate ganglion block) or ketamine, alone or together, can ease headaches and PTSD symptoms after traumatic brain injury. About 175 adults with long-term symptoms will receive real or sham treatments to see what works best. The goal is to impr…

This study tests whether a non-invasive brain stimulation technique called iTBS can help reduce PTSD symptoms when added to standard care. About 140 adults with PTSD will receive the treatment, which uses magnetic pulses to target a brain area involved in movement and possibly em…

This study tests whether adding a smartphone app called PE Coach to standard talk therapy helps veterans with PTSD feel better and function better in daily life. About 124 veterans will be randomly assigned to therapy with or without the app. Researchers will measure changes in P…

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can help veterans with PTSD sleep better and feel less stressed. About 32 veterans will take the drug for 6 weeks while researchers track changes in sleep quality, PTSD symptoms, a…

This study looks at ways to help veterans with PTSD who are not getting better from their first treatment. It will test if switching to a different therapy or getting text message reminders to do homework between sessions improves symptoms. About 300 veterans will take part. The …

This study tests a cognitive behavioral therapy (CBT) program that treats anxiety, PTSD, and alcohol use at the same time in veterans. The goal is to improve daily functioning and quality of life. About 40 veterans with an anxiety disorder and hazardous drinking will participate.…

This study tests a program called Reminder-Focused Positive Psychiatry (RFPP) for teens aged 11-15 with PTSD. The program uses telehealth sessions to help teens cope with trauma reminders and improve well-being. Researchers will compare RFPP to a control group and measure changes…

This study tests a mobile app called MARI designed to help veterans with PTSD who struggle with anger. About 150 veterans will be randomly assigned to use MARI or a health education app. The goal is to see if MARI can reduce anger and improve daily life more than the education ap…

This study tests a brief, two-session program for family members of veterans with PTSD. The goal is to see if this family support helps veterans stay in their own PTSD therapy longer and feel better. About 200 veteran-family pairs will take part. If it works, this simple addition…

This study tests whether a type of talk therapy called Cognitive Processing Therapy (CPT) can reduce heart disease risk in people with PTSD. Thirty adults with PTSD and heart risk factors will receive either CPT or be placed on a waitlist. Researchers will measure changes in brai…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either bright light or a placebo light along with co…

This study looks at whether art therapy can help active-duty military members and recent veterans who have posttraumatic stress symptoms. Participants will attend eight art therapy sessions and have two MRI scans to see how the therapy affects emotional expression and brain activ…

This study tests whether a therapy called EMDR can reduce PTSD symptoms in 60 adults who developed PTSD after a heart attack. Participants will receive EMDR sessions, and researchers will measure PTSD levels and stress responses at 3 and 6 months. If effective, EMDR could become …

This study tests two treatments for insomnia in 200 veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, the other is a relaxation technique. Researchers will see which better improves sleep, daily functioning, and reduces suicidal thoughts over…

This study tests a new type of talk therapy called Multi-Modal Cognitive Processing Therapy (MMCPT) for people with posttraumatic stress disorder (PTSD). The goal is to see if it reduces PTSD symptoms, improves sleep, and helps with anxiety and depression. Sixty adults with PTSD …

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients overcome PTSD. Participants wear VR headsets to safely revisit traumatic experiences in a controlled environment. The goal is to see if this approach is practical and tolerable, and wh…

This study looks at how drinking and PTSD together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to understand these connections better, not to test a treatment.

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties to test if personalized training reduces daily negative emotions…

This study looks at whether a program called the Trauma Resilience and Recovery Program (TRRP) helps people who have been seriously injured get mental health support. About 350 English- or Spanish-speaking adults and teens admitted to a trauma center will take part. Researchers w…

This study looks at how a type of brain stimulation called cTBS affects arousal and fear learning in 120 adults with PTSD. Participants will receive either real or fake stimulation while their startle response and distress are measured. The goal is to understand the brain's role …