Can a Two-Drug combo rewire the PTSD brain?

NCT ID NCT05133804

Recruiting now Disease control Sponsor: University of Haifa Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial investigates whether combining two medications—reboxetine and methylphenidate—can reduce PTSD symptoms by improving attention and emotional regulation. Adults with PTSD will receive either the drug combination or a placebo for about a month, and researchers will measure changes in symptom severity. The study also explores how attention, sensory processing, and emotional regulation are linked in PTSD.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A combination of two drugs: reboxetine (a norepinephrine reuptake inhibitor) and methylphenidate (a stimulant commonly known as Ritalin), taken together to target attention and emotional regulation.
What this could lead to: If successful, this combination could offer a new treatment approach for PTSD that specifically addresses attention and emotional regulation difficulties.
What could go wrong: This is a small, early-stage trial, so results may not be conclusive. The drugs can have side effects, and the combination may not prove more effective than placebo.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type Emotional Regulation post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTTRAUMATIC STRESS DISORDER

Contacts and locations

Locations

Emek Medical Center
RECRUITING

Afula, Israel
Lev HaSharon Mental Health Center
RECRUITING

Netanya, Israel
University of Haifa
RECRUITING

Haifa, Israel

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