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Brain-training game aims to sharpen thinking and ease PTSD in veterans

NCT ID NCT07693686

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 17, 2026 · Updated 4 times

Summary

This study tests a computer-based cognitive training program called COGENT in veterans with PTSD. The program is designed to improve how people manage information in working memory, which may reduce cognitive disability and PTSD symptoms. Researchers will measure changes in thinking, daily functioning, and symptom severity over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
COGENT (Cognitive ENhancement Training) - a computer-administered cognitive training program
What this could lead to
If it works, this could offer a non-drug treatment to help veterans with PTSD think more clearly and feel better day-to-day.
What could go wrong
This is an early-to-mid-stage trial with 176 participants, so results may not apply to all veterans. The training is demanding and may not help everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 176 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2027

An estimate. Start dates often move.

Expected to finish

Mar 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * diagnosis of PTSD * presence of subjective cognitive complaints * fluent in English * willing to attend assessment and treatment sessions Exclusion Criteria: * past year history of psychotic or bipolar I disorders * past year history of severe alcohol or substance use disorder * history of severe traumatic brain injury or other known neurological condition that may be associated with cognitive dysfunction * acute suicidality necessitating immediate clinical intervention (within past 3 months) * presence of circumstances that require imminent intervention prior to other treatment (e.g., current domestic abuse) * plans for medication changes within the study timeframe * current or planned evidence-based psychotherapy for PTSD within the study timeframe * plans for changes to other psychosocial therapy within the study timeframe * presence of life-threatening or unstable medical conditions

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Posttraumatic stress disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • VA San Diego Healthcare System, San Diego, CA

    San Diego, California, 92161-0002, United States

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