POSTTRAUMATIC STRESS DISORDER

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This study tested two common treatments for depression and PTSD—talk therapy (IPT) and an antidepressant (fluoxetine)—in a large public hospital in Kenya. Over 2,100 adults participated to see if these treatments could be effectively delivered by non-specialists in primary care. …

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tested a type of talk therapy called Behavioral Activation (BA) in 10 U.S. veterans who have both alcohol use disorder and PTSD. BA helps people change their daily activities and thinking to reduce drinking and PTSD symptoms. The study compared BA to another therapy ca…

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This study tested three ways to deliver Acceptance and Commitment Therapy (ACT) for adults aged 20-40 with mild to moderate PTSD in Pakistan. Participants were split into three groups: standard clinic therapy, clinic therapy with a supporting web app, and fully online therapy wit…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This study tested whether a short, trauma-focused therapy called Narrative Exposure Therapy (NET) can help low-income urban teens aged 16–25 who have PTSD from violence and are at risk for substance use. Researchers measured changes in PTSD symptoms and alcohol use. The goal was …

This study tested compassion-focused therapy (CFT) in 24 women with complex PTSD who struggle with harsh self-criticism. Over 12 weekly group sessions, participants learned skills to be kinder to themselves. Researchers measured changes in self-criticism, PTSD symptoms, and shame…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested a new type of therapy called reminder-focused positive psychiatry (RFPP) for teenagers who have both ADHD and PTSD. The goal was to see if the therapy is acceptable and helpful for reducing symptoms. Eleven teens took part, and the study measured how well they l…

This study looked at whether a 10-week compassion meditation course is a practical and acceptable treatment for veterans with PTSD. Researchers enrolled 113 veterans across multiple U.S. sites and compared the meditation program to a standard relaxation course. The main goal was …

This study tested a personalized version of cognitive processing therapy (CF-CPT) for veterans with PTSD. 179 veterans participated to see if tailoring therapy to individual needs improves daily functioning, quality of life, and treatment completion compared to standard therapy. …

This study tested a program called MOSAIC Plus for 15 pregnant women and mothers of young children who had experienced intimate partner violence and had symptoms of depression or PTSD. The program lasted 6 months and aimed to reduce those symptoms and prevent further violence. Th…

This study tested whether a single session of playing Tetris after briefly recalling a traumatic childbirth memory could reduce the number of intrusive memories and PTSD symptoms in new mothers. 120 women who had given birth at least six weeks ago and reported frequent intrusive …

This study looked at whether a type of talk therapy called prolonged exposure therapy can help reduce PTSD symptoms in people with spinal cord injuries. Thirty adults with both conditions were randomly assigned to receive the therapy or continue their usual care. The main goal wa…

This pilot study tested a behavioral program called Compensatory Cognitive Training (CCT) in 21 veterans with PTSD who still had memory and attention problems despite prior treatment. CCT teaches practical strategies to work around cognitive difficulties, like using reminders and…

This study tested a personalized magnetic brain stimulation therapy called MeRT for people with PTSD. 158 adults received either real or sham treatment. The goal was to see if MeRT could safely reduce PTSD symptoms. The approach tailors the stimulation to each person's brain wave…

This study tested whether a natural brain chemical called pregnenolone can reduce PTSD symptoms in Iraq and Afghanistan veterans. 96 veterans with PTSD took either pregnenolone or a placebo for 10 weeks and had their symptoms checked regularly. The goal was to see if the suppleme…

This study tested a short video and a 3-week text messaging program for adults who recently experienced sexual assault. The goal was to see if these tools could help prevent or reduce posttraumatic stress disorder (PTSD) and opioid misuse. Fifty participants received the video du…

This study tested a program called the Pregnant Moms' Empowerment Program (PMEP) for pregnant women who had experienced intimate partner violence in the past year. The goal was to see if the program could improve mothers' mental health, reduce the chance of further violence, and …

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms before, during, and after…

This study tested whether adding a stellate ganglion block (a numbing injection in the neck) to cognitive processing therapy (a type of talk therapy) helps reduce PTSD and chronic pain more than therapy alone. Sixty adults with PTSD took part. The goal was to see if the combinati…

This study tested a new program called Adjunctive Family-Cognitive Behavioral Therapy (AF-CBT) for veterans with anxiety disorders. It involved 48 veterans and their family members to see if adding family support to standard therapy was acceptable and helpful. The main goal was t…

This study looked at whether teaching military members to train service dogs can improve symptoms of PTSD, anxiety, depression, and concussion. 156 participants spent one hour twice a week working with professional dog trainers. Researchers measured changes in stress, mood, sleep…

This study looked at a telemedicine program called TOP that helps rural veterans with PTSD get care without traveling far. Over 500 veterans took part. The goal was to see which method of rolling out the program worked better to reach more patients and improve PTSD symptoms.

This study looked at whether treating insomnia can reduce the risk of heart disease in people with PTSD. Researchers measured blood pressure, blood vessel health, and other heart risk factors in 140 adults aged 40-59. The goal was to see if improving sleep could also improve hear…

This study looked at whether people with sensory modulation problems (like being overly sensitive to sounds or touch) are more likely to develop PTSD after a traumatic event. Researchers showed 248 healthy adults a stressful film and tracked their memories, pain sensitivity, and …

This study tested a mobile health tool called CAARE to help children under 12 and their caregivers cope with emotional and behavioral challenges after a traumatic injury. Researchers measured changes in distress, PTSD symptoms, depression, and quality of life in 54 participants. …

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…