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One therapy to treat them all? study tests single approach for PTSD, anxiety, and depression in veterans

NCT ID NCT04293341

Completed Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms before, during, and after treatment, plus at a 6-month follow-up. The goal is to see if one streamlined approach can replace the need for multiple specialized treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transdiagnostic Behavior Therapy (TBT) and Cognitive Processing Therapy (CPT)
What this could lead to
If successful, this could show that one therapy can effectively treat multiple mental health conditions, making treatment simpler and more accessible for veterans.
What could go wrong
This is a completed study, so results are available but may not apply to all veterans. The therapies are behavioral, not drugs, so effects depend on patient engagement and therapist skill.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agoraphobia major depressive disorder panic disorder panic disorder with agoraphobia post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER PANIC DISORDER AND AGORAPHOBIA POSTTRAUMATIC STRESS DISORDER

Contacts and locations

Locations

  • Ralph H. Johnson VA Medical Center, Charleston, SC

    Charleston, South Carolina, 29401-5703, United States

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