Could a common heartburn pill boost chemo against tough prostate cancer?

NCT ID NCT04337580

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding omeprazole (a common heartburn medicine) to standard chemotherapy can help control advanced prostate cancer that has stopped responding to other treatments. About 50 men with castration-resistant prostate cancer will receive either omeprazole plus cabazitaxel or omeprazole plus docetaxel. The goal is to see if the combination shrinks tumors or slows cancer growth.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma neoplasm prostate cancer Prostatic Neoplasms, Castration-Resistant refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • W.G. Bill Hefner VA Medical Center

    RECRUITING

    Salisbury, North Carolina, 28144, United States

    Contact

    Contact Email: •••••@•••••

  • Wake Forest Baptist Comprehensive Cancer Center

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

    Contact

    Contact Email: •••••@•••••