Wake Forest University Health Sciences

This early study is testing whether platelet-rich plasma (PRP) injections can help control female pattern hair loss. Sixteen women will receive monthly injections for three months, with researchers measuring hair regrowth and quality of life. The study uses a 'half-head' design w…

This early-stage study aims to test the safety of a new approach to repair severe penile damage. Doctors will take a small sample of a patient's own penile cells, grow them in a lab on a donor tissue scaffold, and then implant this engineered tissue to repair injuries. The study …

This study is testing whether a combination of telehealth video visits and home blood pressure monitoring can safely manage chronic high blood pressure during pregnancy. It will compare this approach to the standard care of frequent in-person clinic visits. The goal is to see if …

This study is testing if a specially formulated, easy-to-digest liquid diet can help adults manage sudden worsening of their inflammatory bowel disease (IBD) symptoms, known as a flare. The goal is to see if adding this diet to usual care can reduce symptoms and lower the need fo…

This study aims to see if giving doctors daily measurements of pressure in a patient's arm vein helps people hospitalized for worsening heart failure. Researchers will compare standard care to care guided by this pressure reading. They want to find out if this approach helps pati…

This study is testing if adding a specific medication to the spinal fluid can prevent a dangerous complication called vasospasm in patients who have had a brain bleed from a burst aneurysm. Vasospasm causes blood vessels in the brain to narrow, which can lead to a stroke. Researc…

This study is testing a special training method that uses both sight and sound to try to restore vision in people who have lost part of their eyesight after a stroke. Researchers will work with 72 stroke survivors, some with long-term vision loss and others who start training soo…

This study aims to find the better surgical method for fixing broken thigh bones near the knee in adults aged 55 and older. Researchers will compare using one surgical implant versus two to see which helps bones heal more reliably and gets patients back to their normal activities…

This study compares two treatments for septic shock, a life-threatening condition with high mortality. Researchers will test whether giving Angiotensin II works better than the standard treatment (norepinephrine) at stabilizing patients. The trial will also look for better ways t…

This study is testing a new surgical treatment for people with a severe, shrunken bladder that doesn't respond to medication. Doctors will take a small sample of a patient's own bladder cells, grow them in a lab for 5-7 weeks to create a 'neo-bladder' patch, and then surgically a…

This study is testing whether weekly video check-ins from an artificial intelligence (AI) doctor can help people with psoriasis use their prescribed cream more consistently. It will compare the AI check-ins to weekly video calls from a real person and to standard doctor visits. T…

This study is testing if a medication called Vibegron can help improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Over 12 weeks, 40 participants will take either the drug or a placebo pill. Researchers will measure cha…

This study is testing whether providing free, culturally appropriate food bundles and simple recipe guides can help adults with type 2 diabetes who have trouble affording healthy food. The 25 participants are low-income, uninsured patients at a clinic in North Carolina. Researche…

This study compares two types of bone grafts used to treat broken bones that haven't healed properly. Researchers want to see if using donor bone (allograft) helps patients return to work faster than using their own bone (autograft). The trial will enroll 156 adults with non-heal…

This study tests a personalized care program for adults 65 and older who are receiving chemotherapy. Researchers will create individual support plans based on each person's health needs and check in weekly for 12 weeks. The goal is to help manage treatment side effects better and…

This study aims to see how well a new, wearable glucose monitor works for patients having major heart surgery. Researchers will compare the monitor's readings to standard blood glucose tests taken during the operation and recovery. The goal is to understand if this device can pro…

This study is testing if a simple, wearable glucose monitor can replace the standard, burdensome blood sugar test for women after a pregnancy with gestational diabetes. It aims to see if this easier, at-home method helps more women complete their important postpartum screening. T…

This study is testing a community walking program called Walk On! to see if it helps prevent falls in older adults who have trouble moving around or feel socially isolated. Participants will join group walking sessions twice a week for 12 weeks. Researchers want to learn if the p…

This small pilot study is testing whether a gentle, non-invasive electrical stimulation delivered to the scalp during deep sleep can improve that deep sleep in adults with depression. Researchers want to see if boosting deep sleep leads to better memory, thinking speed, and mood.…

This study is testing whether injecting a local anesthetic directly into the penis during implant surgery can better manage pain afterward. Researchers will compare the anesthetic to a saltwater placebo in 100 men getting their first penile implant. The main goal is to see if thi…

This study is testing if using a simple floor pedal bike at home can help adults recover from leg or ankle fractures after surgery. Researchers want to see if the bike is easy for patients to get and use, and if it helps improve their physical activity and function. Participants …

This study is testing whether a short, creative writing exercise can help reduce burnout and stress in healthcare professionals. It will involve 60 faculty doctors from Wake Forest Baptist who will try a brief 'flash writing' activity. The goal is to see if this simple, personal …

This study is testing whether a virtual exercise and health education program helps breast cancer patients maintain their fitness, heart health, and quality of life during chemotherapy. Researchers will enroll 120 patients with early-stage breast cancer who are about to start che…

This study aims to see if adding mindfulness techniques to standard physical therapy can help people with non-flaccid facial paralysis. Researchers will compare two groups: one receiving only physical therapy and another receiving short mindfulness sessions before their therapy. …

This study is testing whether adding a safe, non-invasive electromagnetic therapy (PEMF) to standard bladder medication treatments can better relieve pain and symptoms for women with chronic bladder pain syndrome (IC/BPS). Researchers will give 20 participants a PEMF device to us…

This study aims to see if practicing common, stressful labor scenarios helps reduce fear and anxiety about childbirth. First-time mothers in their third trimester will either participate in simulated experiences or receive standard care. Researchers will then compare their childb…

This study is testing whether using virtual reality (VR) goggles during radiation therapy can help reduce anxiety for cancer patients. Researchers will compare 54 patients with prostate, breast, lung, or head/neck cancer who either use VR during treatment or receive standard care…

This study is testing a vaginal device designed to help women manage chronic bladder pain and pelvic floor muscle tension at home. Participants will use the device three times a week for 12 weeks, applying heat and gentle pressure. The goal is to see if this self-managed therapy …

This study compares two pain management approaches for adults with serious injuries. Researchers want to see if using buprenorphine (a medication sometimes used for opioid addiction) works as well as traditional oxycodone for controlling pain after trauma. The goal is to find eff…

This study aims to find which combination of numbing medications provides longer-lasting pain relief after total knee replacement surgery. Researchers will compare a newer, long-acting numbing medicine against a mix of several standard medications. About 90 adults scheduled for k…

This study is testing a new group exercise program for older adults with a common type of heart failure. The program combines supervised workouts with group counseling and uses remote activity monitors to track progress. The goal is to see if this approach can improve symptoms, p…

This study aims to find the best way to give methadone, a strong pain medication, to patients during heart surgery. Researchers will compare three different dosing schedules in 69 patients to see which one provides the most effective and consistent pain relief after the operation…

This study aims to see if a mindfulness-based training program is as good as, or better than, the standard low-FODMAP diet for managing irritable bowel syndrome (IBS) symptoms. It will involve 30 adults with IBS who will be randomly assigned to try one of the two approaches over …

This study is testing whether giving the hormone oxytocin through an IV during and after hip replacement surgery helps people recover faster. Researchers will compare oxytocin to a placebo in 80 patients to see if it helps them walk more steps daily, feel less pain, and use fewer…

This study is testing whether a simple blood test to check DHA levels can be smoothly added to routine early pregnancy care. It will involve 650 pregnant patients at six clinics. The goal is to see if this screening is practical and well-used, which could help design a future stu…

This study is testing a new communication system called CORRECT, designed to help radiation oncologists and radiologists work together more effectively when planning radiation therapy for lung and head/neck cancers. The goal is to see if this system is practical for doctors to us…

This study aims to find out which warning labels work best on cannabis edible packaging. Researchers will show 1,250 U.S. residents different package designs to see which warnings improve understanding of risks, like accidental overconsumption, and affect people's interest in try…

This study aims to create better surveys to measure how cancer affects the lives of teens and young adults. Researchers will ask 3,000 young people, including those with and without a cancer history, and their caregivers about body image, fertility concerns, and financial stress.…

This study aims to see if sending supportive messages helps people recovering from sepsis share their health information from home. Researchers will compare 200 patients who get these messages to those who don't, to see who is better at providing data. The goal is to learn how to…

This study aims to learn how often children and young adults with cancer have genetic differences that might affect how their bodies process cancer drugs and other medications. Researchers will collect a simple cheek swab from up to 130 participants to analyze their genes. The go…

This study aims to identify where young adults with cancer feel they lack information and support. Researchers will ask 300 participants, diagnosed between ages 15-39, to complete questionnaires about topics like fertility, finances, and emotional health. The goal is to gather in…

This study aims to see if patients who speak directly with an emergency doctor over the phone are more willing to accept ambulance transport to the hospital compared to those who don't. It will involve 250 adults who initially want to refuse the ambulance after calling 911. The g…