Wake Forest University Health Sciences

This trial asks whether adding intranasal insulin or empagliflozin to standard anti-amyloid therapy can improve outcomes for people with mild cognitive impairment or early Alzheimer's disease. Participants will receive one of the two study drugs or a placebo, alongside their pres…

This study tests whether Vibegron, a drug already approved for overactive bladder, can improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Forty participants will take the drug or a placebo for 12 weeks. The goal is to …

This trial tests whether a telemedicine program can help Black patients with high blood pressure get better control. The program includes home blood pressure monitoring, medication management, and support from pharmacists, nurses, community health workers, and social workers. Res…

This early-phase trial tests whether a small enema made from the mother's own breast milk can help very preterm infants (born before 28 weeks) pass their first stool (meconium). Delayed passage can slow feeding and raise the risk of serious gut infections. The study will enroll 2…

This study tests whether a drug called Angiotensin II works better than the usual treatment (norepinephrine) for people with septic shock, a life-threatening condition where blood pressure drops dangerously. About 78 adults with septic shock will receive either Angiotensin II or …

This study tests whether giving the antibiotic azithromycin before a cervical stitch (cerclage) can help high-risk pregnancies last longer. About 80 pregnant women with a weak cervix will receive either azithromycin or a placebo, plus standard care. The goal is to see if the anti…

This study explores whether giving people with mild-to-moderate eczema a straightforward treatment plan using only Opzelura cream helps them stick to their medication routine. Participants apply the cream twice daily until their skin clears, then as needed. Some participants also…

This study tests whether giving doctors daily readings of a patient's peripheral venous pressure (a simple vein pressure measurement) can help heart failure patients get out of the hospital faster and avoid coming back. Researchers will compare 600 patients who get this extra inf…

This early-stage trial is testing whether injecting placental stem cells into and around non-healing diabetic foot ulcers is safe. The study involves 12 people with Type 2 diabetes who have a foot ulcer that has not healed for at least four weeks despite standard care. Researcher…

This phase 1 trial tests whether a powder made from human amnion membrane is safe and can improve healing of scalp wounds after Mohs surgery for skin cancer. About 20 adults with scalp wounds at least 4 cm² will receive either the amnion powder or standard ointment. Researchers w…

This early study is testing a new approach for people whose bladders have become small and scarred, causing frequent urination and discomfort. Doctors will take a small sample of the patient's own bladder cells, grow them in a lab on a special scaffold to create a 'neo-bladder' p…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

This study looks at whether giving antibiotics directly into the bone during surgery can prevent infections in people with osseointegration implants (a type of prosthetic that attaches directly to the bone). About 100 adults who already have or are getting these implants will rec…

This early-stage trial tests a new drug called LP-118 alongside standard treatments for adults newly diagnosed with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). The study will enroll 26 people to find the safest dose and see if the combination helps control the d…

This early-stage trial tests a lab-grown penile tissue made from a man's own cells to repair severe, irreversible damage to the penis. Ten men aged 18-60 who have failed standard treatments will receive the implant. The main goal is to check safety, not effectiveness.

This study tests whether giving a calcium channel blocker (nicardipine) through a lumbar drain can prevent dangerous artery spasms and delayed brain damage in people who have had a brain bleed from a ruptured aneurysm. About 214 adults with mild to moderate bleeds will receive th…

This study compares two surgical procedures for non-healing fractures (nonunion) in long bones like the thigh or shin. One uses the patient's own bone (autograft), the other uses donor bone (allograft). The goal is to see which approach helps people return to work or military dut…

This study tests whether adding short mindfulness sessions (5-10 minutes) before physical therapy can reduce anxiety, depression, and body image concerns in people with non-flaccid facial paralysis. Twenty-four adults with conditions like Bell's palsy or Ramsay Hunt syndrome will…

This early-stage study tests whether platelet-rich plasma (PRP) therapy, made from a participant's own blood, can help women with androgenic alopecia (female pattern hair loss). Sixteen women will receive PRP injections, and researchers will measure changes in hair loss severity …

This study tests whether simulating common stressful events during labor—like a drop in baby's heart rate or an emergency C-section—can reduce fear and anxiety in first-time pregnant women. Fifty women in their third trimester will practice these scenarios and then report their c…

This trial tests whether a new dressing called Pelashield reduces pain and improves scar appearance compared to the standard Xeroform dressing at skin graft donor sites. Each participant will have their donor site split in half, with one half receiving Pelashield and the other Xe…

This study tests whether using a special heating device on the breast before mastectomy and reconstruction is practical and helpful. Forty adult patients will either use the device for one or three cycles, or receive no treatment. The main goal is to see if patients can follow th…

This study tests whether a special liquid diet (elemental diet) can help adults with inflammatory bowel disease (IBD) feel better during a flare. The diet provides all nutrients in an easy-to-digest form. Researchers will track symptom changes and inflammation levels in 42 outpat…

This study tests whether a short, guided writing exercise called flash-writing can help healthcare faculty at Wake Forest Baptist feel less burned out and stressed. About 60 doctors and faculty from internal medicine, surgery, and pediatrics will try the writing method. Researche…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests whether giving magnesium along with the standard drug metoprolol can quickly lower a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. About 196 adults in the emergency room will receive either magnesium or a placebo, plus metoprol…

This study tests a new at-home device called the Floora Pelvic Rehabilitation Vaginal Dilator in 10 women with interstitial cystitis (painful bladder syndrome) and high-tone pelvic floor dysfunction. Participants use the device three times a week for 12 weeks, combining heat and …

This study looks at whether children, teens, and young adults with newly diagnosed osteosarcoma can safely leave the hospital when their methotrexate levels are slightly higher than usual after standard chemotherapy. The goal is to shorten hospital stays without increasing side e…

This study tests whether injecting a long-lasting numbing medicine (Exparel mixed with bupivacaine) into the penis before placing an inflatable penile implant can reduce post-surgery pain and the need for opioid painkillers. One hundred men with erectile dysfunction who are getti…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study looks at three different ways to give methadone during heart surgery to find the best dose for controlling pain afterward. About 69 adults having planned heart surgery will take part. Researchers will measure methadone levels in the blood and ask about pain to see whic…

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will inclu…

This study compares two types of pain-relieving injections for people having knee replacement surgery. One uses a long-acting drug called liposomal bupivacaine, and the other uses a mix of five different medications. The goal is to see which approach provides better pain control …

This study explores whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults will be split into three groups: weekly AI videos, weekly human doctor videos, or standard care (one follow-up vis…

This study follows people with relapsed or refractory multiple myeloma who are scheduled to receive BCMA CAR-T therapy, a type of cell treatment. Researchers will test memory, attention, and other thinking skills at the start and again at 1, 6, and 12 months after the infusion. T…

This trial tests a new communication workflow called CORRECT that helps radiologists and radiation oncologists work together more effectively when planning radiation therapy for lung and head-and-neck cancers. About 194 patients will be involved, and doctors will use a shared sys…

This study will compare two surgical methods for fixing a specific type of broken thigh bone near the knee in people aged 55 and older. Half the participants will get a single implant (a plate or a rod), while the other half will get two implants (a plate plus either a rod or a s…

This study looks at how a child's genes affect the way their body processes cancer medications. By testing 130 children and young adults (up to age 26) with newly diagnosed cancer, researchers hope to find genetic differences that could help doctors choose safer and more effectiv…

This study will test how well the Dexcom G7 continuous glucose monitor works in 100 adults undergoing heart surgery with cardiopulmonary bypass. The device's readings will be compared to standard blood glucose checks during and after surgery. The goal is to see if the monitor sta…

This study aims to reduce medical mistrust and improve HIV prevention among Hispanic/Latino gay and bisexual men in Mecklenburg County, NC. Researchers will train peer navigators to support their social networks for 12 months, then measure changes in mistrust, HIV testing, and Pr…