Wake Forest University Health Sciences

This early-stage study tested combining targeted spine radiation with the immunotherapy drug pembrolizumab in people with advanced spinal tumors pressing on the spinal cord. Only one person enrolled before the study was stopped early. The goal was to see if this treatment approac…

This study looked at a new way to close surgical wounds in women at high risk for complications after gynecologic abdominal surgery. Instead of leaving the wound partially open to heal, the new method closes it partially right after surgery and fully closes it a few days later. T…

This study aimed to see if adding electromagnetic fields to the drug regorafenib could help people with advanced liver cancer live longer without their cancer growing. It was designed for patients who had already tried other treatments. However, the study was stopped early after …

This Phase 1 trial tested a combination of two chemotherapy drugs (gemcitabine and docetaxel) given alongside radiation therapy for adults with large (over 5 cm), high-grade soft tissue sarcoma of the arms or legs. The goal was to find the safest dose and see how well the body to…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study tested a temporary peripheral nerve stimulation system (SPRINT PNS) placed near the knee for up to 60 days to relieve chronic pain from osteoarthritis. Only 12 people were enrolled, and the trial was terminated early. Researchers measured pain intensity, quality of lif…

This study tested a device called BurstDR spinal cord stimulation to help people with painful diabetic neuropathy that didn't get better with standard medicines. The goal was to see if it could cut leg pain by at least half. Only 6 people joined before the study was stopped early…

This study tested whether using a blood flow restriction (BFR) cuff during physical therapy could help people with shoulder injuries regain strength and return to activity faster. Only 3 people took part before the study was stopped early. The approach uses a special tourniquet t…

This study tested a drug called solriamfetol to see if it could safely help people with brain tumors (gliomas) feel more awake, think clearer, and have a better quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for serious side…

This study tested an online support group for young adults (ages 18-39) who had cancer treatment and were feeling anxious or distressed during the COVID-19 pandemic. The goal was to see if teaching healthy coping skills through a virtual group could improve their mood and confide…

This study tested a web-based guide to help people have conversations about COVID-19. It enrolled 30 adults who spoke English or Spanish. The guide offered virtual conversations tailored to different concerns. The study was terminated early, so results are limited.

This study aimed to measure normal brain blood flow in people with mechanical heart pumps (like LVADs or ECMO). Researchers wanted to find target pump settings that might prevent brain injuries. However, the study was terminated early after enrolling only 6 participants, so no us…

This early-phase trial tested whether the antifungal drug ketoconazole could block a protein called tGLI1 in brain tumors. It included 15 people with breast cancer that spread to the brain or with a type of brain cancer called glioma. The study was terminated early, so we have li…

This pilot study tested a program called SHAREDCare, where a navigator helps lung cancer survivors identify their needs and create a plan to address them. The goal was to improve follow-up care after cancer treatment. However, the study was terminated early and included only 5 pe…

This pilot study tested whether continuous glucose monitors (CGMs) could be used in the days before and after surgery to track blood sugar in people with diabetes. Researchers placed a CGM sensor on 22 patients during a preoperative visit and compared its readings to standard fin…

This study compared two biologic meshes, Fortiva and Strattice, used to repair ventral hernias. Researchers planned to track hernia recurrence and mesh-related complications in patients. However, the study was terminated early and only enrolled 6 people, so no reliable conclusion…

This study looked at whether a single IV dose of oxytocin, a natural hormone, could reduce pain from heat on the skin. It included 7 people — some healthy and some with severe knee arthritis. Researchers measured pain scores during a 5-minute heat test. The study was terminated e…