Wake Forest University Health Sciences

This study looks at how well a virtual program called Coach McLungs works in primary care for children aged 5 to 17 with asthma. The program helps families and doctors make decisions together about asthma care. Researchers will track emergency visits and hospital stays to see if …

This study tests whether combining anastrozole and palbociclib can safely control hormone receptor-positive, HER2-negative metastatic breast cancer in postmenopausal women. About 40 participants will receive the drugs either as their first treatment or after initial chemotherapy.…

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either standard care or an enhanced program with remote monitoring and support. The goal is to see which approach better lowers blood pressure t…

This study tests whether adding the drug belantamab mafodotin to a standard three-drug regimen can improve outcomes for people with multiple myeloma, a type of blood cancer. About 70 adults will receive the combination to find the best dose and see how well it controls the cancer…

This study provides expanded access to Omegaven, a fish oil infusion, for infants and children who developed liver disease from long-term IV nutrition. The goal is to lower high liver enzymes and bilirubin levels. Participants are children aged 0-18 who need IV nutrition for at l…

This study looks at whether phentermine, a weight-loss drug approved for short-term use, can be taken safely for up to 2 years to help manage obesity. About 870 adults with obesity or overweight plus related health issues will take the drug and be monitored for weight loss, blood…

This study tests whether adding the drug selinexor to standard chemotherapy can help older adults with untreated acute myeloid leukemia (AML) live longer and achieve remission. About 57 participants will receive either standard chemo alone or chemo plus selinexor, followed by mai…

This study tests a four-drug combination (trilaciclib, pembrolizumab, gemcitabine, and carboplatin) in people with advanced triple-negative breast cancer that cannot be removed by surgery or has spread. The goal is to see how well the treatment shrinks tumors and how safe it is. …

This study tested a new treatment for people with progressive multiple sclerosis (MS), a form of the disease that causes worsening disability. The treatment involved injecting stem cells from amniotic fluid into the spinal fluid over a year. The goal was to see if it was safe and…

This study tests whether adding nivolumab (an immunotherapy drug) can improve the response in people with relapsed/refractory multiple myeloma who did not get a complete response from ide-cel CAR-T therapy. The trial enrolled 1 adult participant with measurable disease and good p…

This study looks at whether using a smartphone app that gives rewards for negative drug tests works for older adults with opioid, cocaine, or methamphetamine use disorders. Researchers will compare how well younger and older participants engage with the app and stay abstinent. Th…

This early study tests whether azelaic acid, a substance that reduces inflammation, can help treat central centrifugal cicatricial alopecia (CCCA), a condition that causes scarring and hair loss in women. Researchers will compare azelaic acid to a placebo in 18 women to see if it…

This study compares two standard psoriasis treatments to see which one causes fewer changes in skin color (light or dark spots) on the legs. About 40 adults with darker skin tones (Fitzpatrick type 3 or higher) will receive either a steroid cream or tapinarof cream. Researchers w…

This study compares two surgical methods for treating high-grade vulvar dysplasia, a precancerous condition. One method uses frozen-section analysis during surgery to ensure all abnormal tissue is removed, while the other is the standard wide local excision. The goal is to see if…

This study aimed to test whether a single injection of a person's own fat-derived cells (stromal vascular fraction) could safely treat knee arthritis caused by a past injury. It was designed for adults aged 18-45 with moderate knee arthritis and significant pain. However, the tri…

This study tested a new treatment plan for people with stage II or III non-small cell lung cancer. First, the main tumor in the lung was treated with a precise, high-dose radiation (SBRT). Then, the lymph nodes in the chest received standard radiation and chemotherapy, followed b…

This study tests a combination of four drugs (daratumumab, carfilzomib, lenalidomide, and dexamethasone) in 39 adults newly diagnosed with multiple myeloma, a blood cancer. The goal is to see how many patients achieve a complete or very deep response after initial treatment. Whil…

This study was designed to see if bitopertin is safe and can lower harmful protoporphyrin IX levels in people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP) who also have early signs of liver damage. It was withdrawn before enrolling any participants, s…

This study tested whether adding enzalutamide to standard hormone therapy and chemotherapy could better control metastatic prostate cancer. Forty men with hormone-sensitive prostate cancer that had spread took part. The goal was to see if the triple combination was safe and more …

This study looks at two forms of vaginal estrogen—cream and tablet—to see which one post-menopausal women prefer for preventing repeat urinary tract infections (UTIs). About 21 women will try both treatments and then choose their favorite. The goal is to find a treatment that wom…

This study compares two pain control methods after robotic prostate removal: one using opioids and one using only non-opioid medicines like ketamine, ketorolac, and acetaminophen. About 100 men aged 40-75 with prostate cancer will participate. The goal is to see if the opioid-fre…

This study looks at whether support from a community health worker can help African American patients with advanced cancer feel better and plan their care. About 160 patients will either get standard care or extra help from a health worker. The goal is to see if this support impr…

This study looks at adults with certain cancers (like lung, breast, kidney, or melanoma) that have spread to the brain. All participants are also receiving immunotherapy. The goal is to see if giving a lower dose of radiation over a few days causes fewer side effects than the sta…

This study looks at whether dance or music classes can boost memory and heart health in people 62 and older who are worried about memory loss but don't have dementia. Researchers will compare taking 1, 2, or 3 classes per week for 6 months to find the best amount. Participants wi…

This study tests an internet-based program called SHINE to help breast cancer survivors manage sexual concerns after treatment. About 340 women who finished primary cancer treatment at least 12 weeks ago will take part. Participants receive online education and tools over 12 week…

This study tests whether a new razor and a special shaving routine (including pre-shave gel and brush) can improve shaving satisfaction and reduce skin irritation, razor bumps, and inflammation in men who get irritated from shaving. About 40 men with mild to moderate razor bumps …

This study looks at whether giving calcium carbonate to pregnant women during labor induction can help shorten the time needed and reduce the need for C-sections. Researchers will compare 250 women who receive calcium carbonate to a historical group. The goal is to find a low-ris…

This study compares two types of stitches used during minimally invasive surgery for pelvic organ prolapse. The goal is to see if barbed sutures can shorten the time it takes to attach mesh to the vagina. About 52 women will take part, and researchers will also check if the repai…

This study aimed to see if gentian violet, a purple dye used as an antiseptic, could help people with hidradenitis suppurativa (HS), a painful skin condition. Participants would have rated changes in redness, drainage, and pain after one treatment. However, the study was withdraw…

This study planned to compare a mindfulness-based eating awareness program with the standard low-FODMAP diet for people with irritable bowel syndrome (IBS). The goal was to see which approach better eases IBS symptoms. However, the study was withdrawn before enrolling any partici…

This study tests if giving the clot-busting drug tenecteplase directly into the brain artery after mechanical clot removal is safe and helps people with severe stroke. About 40 adults who had a large-vessel blockage stroke within the last 4.5 to 24 hours will receive the drug dur…

This study tests a computer program called HN-STAR that helps people who finished treatment for head and neck cancer. Survivors use it to report symptoms and concerns before doctor visits, and doctors get recommendations to address them. The goal is to improve well-being and ensu…

This study tests a relaxation tool called Cereset on 40 nurses from a hospital orthopedic unit. The goal is to see if using Cereset can reduce stress, anxiety, and insomnia, and possibly improve their work performance. Participants will use the device in sessions and researchers …

This pilot study looks at how the weekly medication tirzepatide affects body composition, bone density, and physical abilities in 40 older adults with obesity over nine months. Participants take the drug, track their diet and activity, and attend regular check-ins. The goal is to…

This study tests whether a mobile app (MyCap) can help head and neck cancer patients report their radiation skin rash during treatment. Sixteen patients will use the app while also using KeraStat® cream. The goal is to see if the app is a practical way to collect patient informat…

This study tests whether a TENS device, which sends mild electrical pulses through sticky pads on the skin, can reduce pain from biologic injections in people with psoriasis. About 20 adults will receive one injection without TENS and another with TENS, then rate their pain. The …

This study aimed to test a procedure called middle meningeal artery embolization for people with chronic migraines that don't get better with medication. The goal was to see if blocking a specific blood vessel in the head could reduce migraine disability and pain. However, the st…

This study aimed to see if a supervised exercise program could reduce symptoms and improve quality of life for women with interstitial cystitis (bladder pain syndrome). The study was withdrawn before enrolling any participants, so no results are available. It would have measured …

This program allowed patients aged 12 and older with severe stomach or gut problems like gastroparesis or GERD to try domperidone when standard treatments failed. The goal was to ease symptoms such as nausea, vomiting, and heartburn. The program is no longer available.

This study compares two surgical sling methods (single-incision vs. retropubic) for treating stress urinary incontinence in women undergoing minimally invasive pelvic organ prolapse repair. About 180 women will be randomly assigned to one of the two sling types. The goal is to se…

This study tests a new web-based tool called CONNECT, along with caregiver navigation sessions, to help support people caring for loved ones with stage II-IV lung cancer. The goal is to see if this approach is practical and helpful for caregivers, who often face high stress and h…

This study takes tissue that would normally be thrown away after surgery and uses it to grow cells in the lab. The goal is to develop better ways to study and repair tissues in the future. Up to 1,000 people having surgery at Wake Forest may participate. This research does not of…

This study looks at whether measuring skin hydration at home can help people with dry skin (due to eczema) use their moisturizer more regularly and prevent the dryness from coming back. About 35 adults will use a moisturizer and be placed into one of three groups: no extra remind…

This study looks at whether a continuous glucose monitor (CGM) can be used instead of the standard oral glucose tolerance test to screen for diabetes after pregnancy. About 1,300 women who had gestational diabetes will wear a CGM sensor for a short time. The goal is to see if mor…

This study looks at how hiatal hernia repair surgery changes the flexibility of the area where the esophagus meets the stomach. Researchers will measure this flexibility before and after surgery in 25 adults. They also want to see if these changes relate to patients' quality of l…

This study aimed to see if a special checklist could help doctors avoid physical strain and injuries while performing colonoscopy. It planned to enroll doctors who do colonoscopies weekly and use a posture-analysis tool to measure risk. However, the study was withdrawn before any…

This study looks at why people with acne have trouble using their topical medications as prescribed. Researchers will track 72 adults in the US to measure how often they apply their creams and what factors affect their routine. The goal is to find ways to help patients stick with…

This study looks at whether using a physical activity questionnaire, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors become more active and spend less time sitting. About 20 survivors aged 50 and older who finished their main cancer tr…

This study looks at whether a quick, point-of-care blood test for heart damage can speed up results and reduce ER wait times for 600 adults with chest pain. Researchers compare the new bedside test to standard lab testing. The goal is to improve care without changing how doctors …

This study looks at whether training cancer clinic staff to give a special health check-up (called a geriatric assessment) helps older adults (65+) starting a new cancer therapy. The check-up covers physical health, daily life, and support networks. Researchers want to see if thi…

This study looks at whether regularly measuring the amount of paclitaxel (a chemotherapy drug) in the blood can help doctors give the right dose to kill cancer while limiting nerve damage. About 22 adults with various solid tumors (like lung, breast, or ovarian cancer) will have …

This study looks at whether a reporting system helps psoriasis patients take their medication (deucravacitinib) as prescribed. Forty adults with moderate-to-severe psoriasis will be split into two groups: one uses a reporting tool, the other does not. Researchers will interview p…

This study looks at how community cancer clinics ask patients about social needs like food, housing, or transportation. Researchers will work with 144 clinic staff to find out what helps or hinders these screenings. The goal is to create custom plans so clinics can better connect…

This study looks at 800 people already enrolled in an Alzheimer's research center. Researchers use a special brain scan to measure amyloid, a protein linked to Alzheimer's. The goal is to see how amyloid builds up over time, which may help find the best time to start treatments i…

This study follows 403 women with early-stage breast cancer to see how chemotherapy affects their heart, ability to exercise, and fatigue levels. Researchers compare these women to people without cancer to better understand long-term side effects. The goal is to gather knowledge,…

This study aimed to see if sending supportive messages to sepsis survivors after hospital discharge would encourage them to regularly share health data through an online portal. The study was withdrawn before enrolling any participants, so no results are available. It was designe…

This study looks at whether adults aged 50 and older with ovarian or endometrial cancer are willing and able to complete physical and cognitive tests before and after their standard cancer treatment. Researchers want to see how many people agree to join, start the tests, and fini…

This study looks at 100 babies leaving the NICU to see if being able to eat a full amount of milk means they have fully developed feeding skills. Researchers will use a special tool to score feeding abilities. The goal is to better understand infant feeding readiness at discharge…

This study follows 94 women aged 50 and older with early-stage, low-risk breast cancer who received a single dose of radiation during surgery (IORT). Researchers track cancer recurrence, side effects, and quality of life over time. The goal is to gather real-world data on how wel…

This study looks at 23 people with advanced non-small cell lung cancer who finished at least 20 months of immunotherapy. Researchers want to see if certain immune markers or DNA in the blood can predict if the cancer will come back. The goal is to better understand who might need…

This study follows about 793 people with chronic kidney disease who already took part in a program to help them get kidney transplants. Researchers want to see if the program's effects last, like whether patients talk to doctors and family about transplants or find living donors.…

This study looks at whether a telehealth system can help rural patients with heart problems get better care. It connects local emergency teams and clinics with heart specialists at a larger medical center. About 215 adults with heart symptoms will take part. The goal is to see if…

This study follows 350 head and neck cancer survivors about 7 years after radiation therapy to see how their teeth, gums, and jawbone are doing. Researchers will check for cavities, gum disease, tooth loss, bone damage, and dry mouth. The goal is to understand long-term dental pr…

This study looks at two methods to help people with lung cancer hold their breath during a special type of radiation called SBRT. One method uses a camera system (SGRT) alone, and the other adds small markers placed in the lung. The goal is to see which method is safer and more r…