Wake Forest University Health Sciences

This study is testing two different telehealth strategies to help people control their blood pressure after having a stroke. Researchers are working with 86 stroke survivors to see which remote monitoring and support approach works better at lowering blood pressure over 6 months.…

This study aimed to test the safety of an investigational drug called bitopertin in adults with a rare disorder called protoporphyria, which can cause severe pain from sunlight and sometimes damage the liver. The goal was to see if daily bitopertin could lower harmful substances …

This study aimed to test the safety and potential benefits of a new stem cell therapy for people with progressive multiple sclerosis (MS). Researchers planned to inject stem cells from amniotic fluid directly into the spinal fluid of participants over a year. The goal was to see …

This study is testing a virtual coaching tool called 'Coach McLungs' to help children and teens with asthma and their doctors make better treatment decisions together. The goal is to see if using this tool in regular doctor's offices can help improve asthma control and reduce tri…

This program provides access to an intravenous fish oil treatment (Omegaven) for infants and children whose livers have been damaged by long-term IV nutrition. The goal is to see if replacing standard IV fats with this fish oil formula can reverse the liver injury. This allows ch…

This study is comparing two different types of surgical stitches used to attach a supportive mesh during a common procedure for pelvic organ prolapse in women. Researchers want to see if a newer 'barbed' stitch is faster to use than traditional individual stitches, while still be…

This study is testing whether a smartphone app that gives cash rewards for passing drug tests helps people with opioid, methamphetamine, or cocaine addiction stay clean. It specifically wants to see if the app works as well for adults aged 55 and older as it does for younger adul…

This study is testing a combination of four drugs (daratumumab, carfilzomib, lenalidomide, and dexamethasone) for people newly diagnosed with multiple myeloma, a cancer of the blood. The goal is to see how well this intensive treatment works to control the disease and achieve a d…

This study compares two approved psoriasis creams to see which one causes fewer skin color changes after treatment. Forty adults with psoriasis on their legs will use either a steroid cream or tapinarof cream daily for up to 12 weeks. Researchers will photograph and measure any s…

This study is testing a computer program called HN-STAR, designed to help people who have finished treatment for head and neck cancer. Survivors use the program to report their symptoms and concerns before a doctor's visit, which helps their care team create a personalized follow…

This study is testing the safety and feasibility of using two drugs, anastrozole and palbociclib, together to control advanced breast cancer that has spread. It is for postmenopausal women whose cancer is hormone-sensitive and HER2-negative. The trial has two groups: one testing …

This study is checking if the weekly medication tirzepatide, along with diet and activity coaching, helps older adults with obesity lose fat while keeping their muscles strong and bones healthy. Over 9 months, 40 participants will take the medication, track their weight and food,…

This small, early-stage study is testing whether a cream containing azelaic acid can help control Central Centrifugal Cicatricial Alopecia (CCCA), a type of scarring hair loss that mostly affects women. Researchers are comparing the cream against a placebo to see if it reduces in…

This study is testing whether combining four different cancer drugs works better against advanced triple-negative breast cancer, which is particularly hard to treat. The trial will enroll 36 patients to see if this combination can shrink tumors and control the disease while being…

This study is testing two different techniques for delivering a precise type of radiation treatment (SBRT) to lung tumors while patients hold their breath. The goal is to see which method causes fewer lung side effects and is more reliable at hitting the tumor accurately. It will…

This early-stage study aimed to test the safety and feasibility of a single injection of a patient's own processed fat tissue into the knee to treat arthritis that developed after a significant injury. The goal was to see if this approach could help younger, active adults with pe…

This study is testing whether adding a new oral drug called selinexor to standard chemotherapy helps older adults with a newly diagnosed, aggressive blood cancer called acute myeloid leukemia (AML). The goal is to see if this combination helps patients live longer and better cont…

This study is testing whether giving a clot-dissolving drug directly into the brain's arteries after a clot removal procedure is safe and helpful for stroke patients. It involves 40 people who have had a major stroke caused by a large blood clot. The goal is to see if this extra …

This study is testing a multi-step treatment for people with stage II or III non-small cell lung cancer. It combines precise, high-dose radiation to the main tumor with standard chemotherapy and radiation to nearby lymph nodes, followed by an immunotherapy drug. The main goal is …

This study is testing whether connecting rural paramedics, emergency rooms, and clinics with heart specialists via video calls improves care for people with chest pain or trouble breathing. It involves about 215 adult patients in Wilkes County. The goal is to see if this teleheal…

This study is observing women with early-stage, low-risk breast cancer who receive a single dose of radiation during their lumpectomy surgery. The goal is to track how well this one-time treatment works over 5 to 10 years, including cancer recurrence rates and side effects. It al…

This study is testing whether adding a newer drug called enzalutamide to the standard two-drug treatment (androgen deprivation therapy plus docetaxel chemotherapy) works better for men with prostate cancer that has spread. The goal is to see if this three-drug combination is safe…

This study is testing if a portable, bedside blood test for heart attacks can give results faster than sending samples to the main hospital lab. It involves 600 adults who come to the emergency room with chest pain. Researchers want to see if getting results quicker helps doctors…

This study aims to find out if post-menopausal women with recurrent urinary tract infections (UTIs) prefer using a vaginal estrogen cream or a vaginal estrogen tablet to help prevent future infections. Twenty-one participants will try each treatment for three months, and research…

This study aims to find the ideal weekly schedule of dance or music appreciation classes to help support memory and heart/lung fitness in older adults who are worried about their memory but do not yet have a diagnosis. Researchers will enroll 165 adults aged 62+ and assign them t…

This study aims to find the best way to help families reschedule important child checkups they've missed. It will compare sending a simple text message reminder to having a community health worker make a personal phone call, against the usual practice of no specific follow-up. Th…

This study aimed to test a simple checklist designed to help doctors avoid painful, work-related injuries while performing colonoscopies. It planned to have 100 doctors at 10 clinics use the checklist before procedures to see if it improved their posture and reduced injury risk. …

This study is testing whether tracking skin hydration helps people with eczema-related dry skin use their moisturizer more consistently. Thirty-five adults will use a prescribed moisturizer and be assigned to either track their skin moisture daily with a device, answer weekly sur…

This study is testing whether giving calcium carbonate, a common over-the-counter supplement, to pregnant people during labor induction can make the process better. Researchers want to see if it shortens the time needed for induction medicine, lowers the chance of a difficult lab…

This study compares two approaches to managing pain after robotic prostate cancer surgery. One group receives standard opioid pain medication, while the other receives a combination of non-opioid drugs like ketamine, ketorolac, and acetaminophen. Researchers want to see if the op…

This study aimed to test if a procedure called middle meningeal artery embolization could help people with chronic migraines that don't get better with medication. The procedure, which blocks a specific artery in the head, would be tested in patients who had tried and failed at l…

This study is testing whether adding a community health worker to standard care improves quality of life for African American patients with advanced cancer. Researchers will compare outcomes between patients receiving standard care alone and those who also get support from a trai…

This study is testing whether a non-invasive audio intervention can help improve the well-being and work performance of nurses and staff in a hospital unit. Up to 40 staff members will receive sessions where they listen to tones that echo their own brainwave activity. Researchers…

This study is testing whether a new razor technology, used alone or with a special pre-shave gel and brush, can improve shaving satisfaction and reduce skin irritation in men. It involves 40 men who have experienced skin bumps and irritation from shaving for at least two years. P…

This FDA program provided domperidone to patients with severe gastroparesis and other stomach disorders who didn't respond to standard treatments. The medication helps move food through the digestive system to relieve symptoms like nausea and vomiting. The program was specificall…

This study is testing a new web-based program called CONNECT, designed to help caregivers of people with stage II-IV lung cancer. The program aims to identify caregivers' specific needs and connect them with helpful support services and resources. Researchers are comparing this p…

This study aimed to test if a supervised exercise program could help relieve pain and improve symptoms for women with interstitial cystitis/bladder pain syndrome, a chronic condition that causes bladder discomfort and urinary problems. Researchers wanted to see if exercise could …

This study is testing if a small, non-drug device called TENS can reduce the pain people feel when they inject their psoriasis medication. About 20 adults with psoriasis will try getting one injection with the TENS device on and one without, then report their pain levels. The goa…

This study is testing an online program called SHINE designed to help breast cancer survivors manage sexual concerns that often arise after treatment. About 340 participants will try different combinations of web-based lessons about sexual health, talking to doctors, communicatin…

This study is testing if metformin, a medication commonly used for diabetes, can help older adults with a specific type of heart failure feel better. Researchers will give 86 participants either metformin or a placebo pill for 20 weeks to see if it improves their ability to exerc…

This study aimed to see if applying a common antiseptic dye called gentian violet could help people with hidradenitis suppurativa (HS), a painful and chronic skin condition. Researchers planned to survey patients about their pain, skin redness, and drainage before and after a sin…

This study is comparing two ways to manage severe pain from cancer. One group gets a small pump implanted near the spine to deliver pain medicine directly. The other group continues with standard pain pills. Researchers will track which method better controls pain, reduces medica…

This study aims to collect healthy and diseased tissue that is normally thrown away after surgeries. Researchers will use these samples to grow cells in the lab and create a library of cell lines. These cells will be used for future research to better understand diseases and deve…

This study aims to understand how chemotherapy for breast cancer affects heart function, exercise capacity, and fatigue. It follows about 400 women with early-stage breast cancer and compares them to women without cancer over two years. Researchers will use heart scans, walking t…

This study aims to learn if certain markers in the blood can predict whether lung cancer will return after patients finish a standard course of immunotherapy. Researchers will follow 23 patients who have completed about two years of treatment, collecting their blood every few mon…

This study aims to understand why people with moderate-to-severe psoriasis sometimes don't take their oral medication as prescribed. Researchers will interview 40 patients to learn what helps some people stick to their treatment plan and what makes it hard for others. They will a…

This study aims to see if doctors can reliably measure the amount of a common chemotherapy drug (paclitaxel) in a patient's blood. The goal is to learn if tracking these levels can help find the right dose to fight cancer while reducing a severe side effect: nerve damage that cau…

This study looks at whether babies leaving the neonatal intensive care unit (NICU) who can drink a full bottle or breastfeed enough are also skilled at feeding. Researchers will review records for 100 babies to see if their feeding skill level matches their ability to take in eno…

This study aims to understand and improve how community cancer clinics screen patients for health-related social needs, such as housing, food, or transportation. It involves observing clinic processes and interviewing staff and patients to identify what helps or hinders these scr…

This study follows head and neck cancer survivors to understand the long-term dental effects of their radiation treatment. Researchers are checking in with about 350 people from a previous study roughly 7 years after their radiation therapy started. They are measuring problems li…

This study is testing whether providing training and support to cancer clinic staff helps them deliver a special health check-up for older adults starting new cancer treatments. The check-up looks at a patient's overall physical health, support network, and daily life impact, not…

This study aims to understand how hiatal hernia repair surgery affects the tightness of the valve between the esophagus and stomach. Researchers will measure this valve's stretchiness during surgery in 25 patients and then check if those measurements relate to patients' heartburn…

This study aims to understand why people with acne sometimes don't use their prescription creams as directed. Researchers will track 72 adult acne patients to see how often they actually use their medications and what factors make it harder to stick to the routine. The goal is to…

This study uses special brain scans to measure and track a protein called amyloid in the brains of 800 people. It includes adults with and without memory problems who are already part of an Alzheimer's research center. The goal is to understand how amyloid buildup relates to the …

This study aims to gather information to design a better, more manageable care plan for people who have both cancer and COPD (a chronic lung disease). Researchers will interview 100 patients and healthcare providers to understand the challenges of managing both conditions. The go…