Old Weight-Loss drug gets a second look: can it work for years?

NCT ID NCT05176626

First seen Apr 25, 2026 · Last updated Apr 28, 2026 · Updated 1 time

Summary

This study looks at whether the weight-loss drug phentermine, which is currently only approved for short-term use (up to 12 weeks), can be safely used for up to 2 years. Researchers will track weight loss, blood pressure, and other health measures in 870 adults with obesity or overweight plus related health issues. The goal is to see if long-term use helps manage obesity as a chronic condition.

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Contacts and locations

Locations

  • Atrium Health Wake Forest Baptist Weight Management Center

    Winston-Salem, North Carolina, 27104, United States

  • HealthPartners Institute

    Saint Louis Park, Minnesota, 55416, United States

  • Kaiser Permanente Southern California

    Los Angeles, California, 90034, United States

  • UT Center for Obesity Medicine and Metabolic Performance

    Bellaire, Texas, 77401, United States

Conditions

Explore the condition pages connected to this study.